Protein Info for EX31_RS06775 in Rahnella sp. WP5

Annotation: iron-containing alcohol dehydrogenase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00465: Fe-ADH
  • amino acids 9 to 346 (338 residues), 168.1 bits, E=2.6e-53
• PF13685: Fe-ADH_2
  • amino acids 15 to 278 (264 residues), 102 bits, E=4.7e-33

Best Hits

KEGG orthology group: K00005, glycerol dehydrogenase [EC: 1.1.1.6] (inferred from 99% identity to rah:Rahaq_2167)

Predicted SEED Role

"Glycerol dehydrogenase (EC 1.1.1.6)" in subsystem Respiratory dehydrogenases 1 (EC 1.1.1.6)

MetaCyc Pathways

• glycerol degradation to butanol (13/16 steps found)
• glycerol degradation II (2/2 steps found)
• glycerol degradation V (1/2 steps found)
• superpathway of glycerol degradation to 1,3-propanediol (2/4 steps found)

KEGG Metabolic Maps

• Glycerolipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.6

Use Curated BLAST to search for 1.1.1.6

Protein Sequence (361 amino acids)

>EX31_RS06775 iron-containing alcohol dehydrogenase family protein (Rahnella sp. WP5)
MQAQNIIFPAQILRGPGVISQLGDICALLGTRALVIGGHQSLAAVGDKIRHQLEGSAVEL
VGSEWFGGESSEGNISRLAKIVKDKKADIVIGVGGGKSLDTCKAVGVETNVPVVTIPTIA
ATCAAVTPLTIRYHDDGHFRDLFPLPQAPASVIIDSEILAVAPLRWLAAGLGDTLAKWYE
FRAISSHHGQLSGVARSSSANSRICYDLIESYGPAACDAVRAGKPNAGLDQVLDAIFMFA
GLTSLMSSGAHAAASHAIYEGFTVCDKTREFGHGLLVGFGNLCLLALENRSDEELLEAVR
LAQACAVPLRLSEIADLNEDELESIVQASLHAPDMANMPEQVTAEALYAAIARVEEMGAR
I