Protein Info for EX31_RS06725 in Rahnella sp. WP5

Annotation: histidine utilization repressor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 272 TIGR02018: histidine utilization repressor" amino acids 41 to 269 (229 residues), 327.7 bits, see alignment E=1.7e-102 PF00392: GntR" amino acids 43 to 105 (63 residues), 73 bits, see alignment E=1.9e-24 PF07702: UTRA" amino acids 126 to 263 (138 residues), 120.1 bits, see alignment E=1e-38

Best Hits

Swiss-Prot: 60% identical to HUTC_PSEAE: Histidine utilization repressor (hutC) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K05836, GntR family transcriptional regulator, histidine utilization repressor (inferred from 100% identity to rah:Rahaq_2157)

Predicted SEED Role

"Histidine utilization repressor" in subsystem Histidine Degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (272 amino acids)

>EX31_RS06725 histidine utilization repressor (Rahnella sp. WP5)
MSEPTPLSQHGAAPHQVTQQQGVSQQTLSELAAAMSDTPAPIYQRVKQAIISQIRAGVWK
PHQRVPSESELVNEIGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAYTPMLEVHNI
ADEIAQRGHRHDSKILVCEARLADADQALQLGIATGTMMFYSQIVHYENNVAVQIEDRFV
NPETAPDYLQQVLNKQTPYTYLMEIAPLTAGEHRVEAISASDEQRELLQLNEHEPCLLIH
RRTWSGSRVVTSARLIYPGSRYQLFGRFTSHG