Protein Info for EX31_RS01185 in Rahnella sp. WP5

Annotation: two-component system sensor histidine kinase DcuS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 539 transmembrane" amino acids 21 to 42 (22 residues), see Phobius details amino acids 182 to 202 (21 residues), see Phobius details PF17203: sCache_3_2" amino acids 51 to 179 (129 residues), 60.2 bits, see alignment E=7.2e-20 PF00989: PAS" amino acids 222 to 319 (98 residues), 25.6 bits, see alignment E=3.2e-09 PF14689: SPOB_a" amino acids 338 to 379 (42 residues), 30.2 bits, see alignment 8e-11 PF02518: HATPase_c" amino acids 430 to 532 (103 residues), 72.8 bits, see alignment E=9.1e-24 PF14501: HATPase_c_5" amino acids 430 to 525 (96 residues), 30.7 bits, see alignment E=7.5e-11

Best Hits

KEGG orthology group: K07701, two-component system, CitB family, sensor histidine kinase DcuS [EC: 2.7.13.3] (inferred from 100% identity to rah:Rahaq_5034)

Predicted SEED Role

"Fumarate respiration sensor kinase protein DcuS"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (539 amino acids)

>EX31_RS01185 two-component system sensor histidine kinase DcuS (Rahnella sp. WP5)
MSDSQQRHSVRKHPMKLSTSVSLMISAVIASVLLVVHMLYFVQVSDTTRDGVKEKALAVA
RTMADLPETKRALLLPPDSNIIQPIASAVQKRNDLLFIVVTNMDGIRYSHPNADVISHHF
IGDDINPALLGNENVSINKGTLDKALRVFTPVYDDHHKQIGVVAIGISLVKVTEQINKSR
WSILWTVLFGLMVGALGTYCLVKLLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDD
QAHVTLINQTARQTFRETAIDVTPDADSLPLIANLRDVLNTGVPRRDEEINFKGRLLLSN
TVPVRNNGVIIGAICTFRDKTEVSQLMQRLSGMVNYADSLRERSHEFMNKLHVILGLLHM
KSYAQLEDYILKTANNYQAEIGSLLLKIKSPVIAGFLLSKMNRASDTRHLLTLSDDSLLP
DNNNEDQVAALITVLGNLIENALDALGDQPDGEVSVLLHYQNGSLACIVSDDGPGIQPEN
IDAIFEKGVSSKGDQRGMGLFLAKQQVESLGGTITVESEPDVYTQFFVQLPWDAERTNS