Protein Info for ECOLIN_RS26975 in Escherichia coli Nissle 1917

Annotation: GntP family permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 449 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details transmembrane" amino acids 27 to 46 (20 residues), see Phobius details amino acids 55 to 76 (22 residues), see Phobius details amino acids 99 to 127 (29 residues), see Phobius details amino acids 135 to 154 (20 residues), see Phobius details amino acids 174 to 193 (20 residues), see Phobius details amino acids 228 to 249 (22 residues), see Phobius details amino acids 261 to 285 (25 residues), see Phobius details amino acids 305 to 326 (22 residues), see Phobius details amino acids 347 to 380 (34 residues), see Phobius details amino acids 387 to 412 (26 residues), see Phobius details amino acids 424 to 448 (25 residues), see Phobius details PF02447: GntP_permease" amino acids 1 to 448 (448 residues), 604.3 bits, see alignment E=1.3e-185 TIGR00791: transporter, gluconate:H+ symporter (GntP) family" amino acids 1 to 449 (449 residues), 654 bits, see alignment E=6.3e-201 PF03600: CitMHS" amino acids 14 to 377 (364 residues), 56 bits, see alignment E=3.9e-19

Best Hits

Swiss-Prot: 100% identical to YJHF_ECOLI: Uncharacterized permease YjhF (yjhF) from Escherichia coli (strain K12)

KEGG orthology group: K03299, gluconate:H+ symporter, GntP family (inferred from 100% identity to eco:b4296)

Predicted SEED Role

"Gluconate permease, Bsu4004 homolog" in subsystem D-gluconate and ketogluconates metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (449 amino acids)

>ECOLIN_RS26975 GntP family permease (Escherichia coli Nissle 1917)
MPLIIVVAGIALLLLLTIKIKLNTFVSLIIVSIAVAIASGMDLSKVVTSVESGLGGTLGH
IGLIFGFGVMLGRLLADAGGAQRIALTMLNYFGKNKLDWAVVCSAFIVGIALFFEVGLIL
LVPILFAIAREAKISPMFMCVPMLSGLLVAHGFLPPHPGPTVIAREYGADVGLVLIYGII
VGIPTFILCGPVLNKFCQRIIPDAFKKEGNIASLGATRRFSESEMPGFGISFLTAMLPVI
LMAVVTIIQMTHAKSAADSGLFYNVILFLGNSTIAMLISLLFAIYTMGLGRGKTIPDLMD
SCGKAIAGIAGLLLIIGGGGAFKQVLIDSGVGQYISTLVSGMDINPILMAWGVAAFLRIC
LGSATVAAISTAGLVIPLLAVHPNTNLALITLATGAGSCICSHVNDASFWMIKDFFGLTT
KETLLSWTLMSTLLSISGLIFILLASLVL