Protein Info for ECOLIN_RS26205 in Escherichia coli Nissle 1917

Annotation: aldo/keto reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 329 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details PF00248: Aldo_ket_red" amino acids 16 to 309 (294 residues), 266.2 bits, see alignment E=1.6e-83

Best Hits

Swiss-Prot: 46% identical to AKR2_ORYSJ: Probable aldo-keto reductase 2 (Os04g0338000) from Oryza sativa subsp. japonica

KEGG orthology group: None (inferred from 99% identity to ect:ECIAI39_0389)

Predicted SEED Role

"Aldo-keto reductase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (329 amino acids)

>ECOLIN_RS26205 aldo/keto reductase (Escherichia coli Nissle 1917)
MQKRYLGKSGLEVSALGLGCMGLSHGYGPATDTRQAIELIRAAVERGVTFFDTAEVYGPY
LNEEVVGEALKPFRDRVVIATKFGFTFGNDNKQQILNSRPEHIREAVEGSLRRLKTDVID
LLYQHRVDPDVPIEDVAGTVKDLIAEGKVKHFGLSEAGAQTIRRAHAVQPVTALQSEYSM
WWREPEQEILPLLEELGIGFVPFSPLGKGFLTGAIKPGTTFGKDDYRSTVPRFAAQAIEA
NEKLVTLLGELAAEKGVTSAQIALAWLLAQKPWIVPIPGTTKLHRLEENLAAADIVLSQK
DTQQISEALETIKIVGERYSPEHQARVGR