Protein Info for ECOLIN_RS21940 in Escherichia coli Nissle 1917

Annotation: threonine export protein RhtC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 206 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 38 to 63 (26 residues), see Phobius details amino acids 68 to 87 (20 residues), see Phobius details amino acids 119 to 140 (22 residues), see Phobius details amino acids 152 to 173 (22 residues), see Phobius details amino acids 185 to 204 (20 residues), see Phobius details PF01810: LysE" amino acids 14 to 205 (192 residues), 205.8 bits, see alignment E=2.4e-65 TIGR00949: homoserine/Threonine efflux protein" amino acids 18 to 202 (185 residues), 233.7 bits, see alignment E=6.5e-74

Best Hits

Swiss-Prot: 99% identical to RHTC_ECOLI: Threonine efflux protein (rhtC) from Escherichia coli (strain K12)

KEGG orthology group: K05835, threonine efflux protein (inferred from 99% identity to eco:b3823)

MetaCyc: 99% identical to L-threonine exporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-0244

Predicted SEED Role

"L-lysine permease" in subsystem Lysine degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (206 amino acids)

>ECOLIN_RS21940 threonine export protein RhtC (Escherichia coli Nissle 1917)
MLMLFLTVAMVHIVALMSPGPDFFFVSQTAVSRSRKEAMMGVLGITCGVMVWAGIALLGL
HLIIEKMAWLHTLIMVGGGLYLCWMGYQMLRGALKKEVVSAPAPQVELAKSGRSFLKGLL
TNLANPKAIIYFGSVFSLFVGDNVGTTERWGIFALIIVETLAWFTVVASLFALPQMRRGY
QRLAKWIDGFAGALFAGFGIHLIISR