Protein Info for ECOLIN_RS15635 in Escherichia coli Nissle 1917

Annotation: L-fucose operon activator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 243 PF08279: HTH_11" amino acids 5 to 48 (44 residues), 36.3 bits, see alignment 1.1e-12 PF08220: HTH_DeoR" amino acids 5 to 60 (56 residues), 75.6 bits, see alignment E=5.1e-25 PF00455: DeoRC" amino acids 76 to 233 (158 residues), 155.2 bits, see alignment E=3.7e-49

Best Hits

Swiss-Prot: 99% identical to FUCR_SHIFL: L-fucose operon activator (fucR) from Shigella flexneri

KEGG orthology group: K02430, DeoR family transcriptional regulator, L-fucose operon activator (inferred from 99% identity to eco:b2805)

Predicted SEED Role

"L-fucose operon activator" in subsystem L-fucose utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (243 amino acids)

>ECOLIN_RS15635 L-fucose operon activator (Escherichia coli Nissle 1917)
MKAARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYIHR
QNQDSGDPFHIRLKSHYAHKADIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVF
TNSHPICHELGKRERIKLISSGGTLERKYGCYVNPSLISQLKSLEIDLFIFSCEGIDSSG
ALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVTTSL
VTA