Protein Info for ECOLIN_RS14410 in Escherichia coli Nissle 1917

Annotation: zinc-binding dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 364 PF08240: ADH_N" amino acids 39 to 153 (115 residues), 100.7 bits, see alignment E=8.3e-33 PF16912: Glu_dehyd_C" amino acids 187 to 349 (163 residues), 36.5 bits, see alignment E=7.3e-13 PF00107: ADH_zinc_N" amino acids 196 to 323 (128 residues), 92.4 bits, see alignment E=4.6e-30 PF13602: ADH_zinc_N_2" amino acids 249 to 360 (112 residues), 28.2 bits, see alignment E=6.8e-10

Best Hits

Swiss-Prot: 99% identical to YPHC_ECOLI: Uncharacterized zinc-type alcohol dehydrogenase-like protein YphC (yphC) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 99% identity to ecw:EcE24377A_2830)

Predicted SEED Role

"Hypothetical zinc-type alcohol dehydrogenase-like protein YphC" in subsystem Unknown sugar utilization (cluster yphABCDEFG)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (364 amino acids)

>ECOLIN_RS14410 zinc-binding dehydrogenase (Escherichia coli Nissle 1917)
MKINRIVNEGFMKTMLAAYLPGNSTVDLREVAVPTPGINQVLIKMKSSGICGSDVHYIYH
QHRATAAAPDKPLYQGFINGHEPCGQIVAMGQGCRHFKEGDRVLVYHISGCGFCPNCRRG
FPISCTGEGKAAYGWQRDGGHAEYLLAEEKDLILLPDALSYEDGAFISCGVGTAYEGILR
GEVSGSDNVVVVGLGPVGMMAMMLAKGRGAKRIIGVDMLPERLAMAKQLGVMDHGYLATT
EGMPQIIAELTHGGADVALDCSGNAAGRLLALQSTADWGRVVYIGETGKVEFEVSADLMH
HQRRIIGSWVTSLFHMEKCAHDLTDWKLWPRNAITHRFSLEQAGDAYALMASGKCGKVVI
NFPD