Protein Info for ECOLIN_RS11180 in Escherichia coli Nissle 1917

Annotation: glyoxalase III HchA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.

Best Hits

Swiss-Prot: 100% identical to HCHA_ECOL5: Protein/nucleic acid deglycase HchA (hchA) from Escherichia coli O6:K15:H31 (strain 536 / UPEC)

KEGG orthology group: K05523, molecular chaperone HchA (Hsp31) (inferred from 99% identity to eco:b1967)

MetaCyc: 99% identical to protein/nucleic acid deglycase 1 (Escherichia coli K-12 substr. MG1655)
GLYOXIII-RXN [EC: 4.2.1.130]; RXN-17630 [EC: 4.2.1.130, 3.5.1.124]; 3.5.1.124 [EC: 4.2.1.130, 3.5.1.124]; 3.5.1.124 [EC: 4.2.1.130, 3.5.1.124]

Predicted SEED Role

"Chaperone protein hchA"

MetaCyc Pathways

• methylglyoxal degradation IX (1/1 steps found)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.1.124 or 4.2.1.130

Protein Sequence (283 amino acids)

>ECOLIN_RS11180 glyoxalase III HchA (Escherichia coli Nissle 1917)
MTVQTSKNPQVDIAEDNAFFPSEYSLSQYTSPVSDLDGVDYPKPYRGKHKILVIAADERY
LPTDNGKLFSTGNHPIETLLPLYHLHAAGFEFEVATISGLMTKFEYWAMPHKDEKVMPFF
EQHKSLFRNPKKLADVVASLNADSEYAAIFVPGGHGALIGLPESQDVAAALQWAIKNDRF
VISLCHGPAAFLALRHSDNPLNGYSICAFPDAADKQTPDIGYMPGHLTWYFGEELKKMGM
NIINDDITGRVHKDRKLLTGDSPFAANALGKLAAQEMLAAYAS