Protein Info for ECOLIN_RS10935 in Escherichia coli Nissle 1917

Annotation: cystine ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00497: SBP_bac_3
  • amino acids 43 to 261 (219 residues), 246.6 bits, E=2e-77
• PF10613: Lig_chan-Glu_bd
  • amino acids 63 to 135 (73 residues), 42.1 bits, E=8.7e-15

Best Hits

Swiss-Prot: 100% identical to FLIY_ECOLI: L-cystine-binding protein FliY (fliY) from Escherichia coli (strain K12)

KEGG orthology group: K02424, cystine transport system substrate-binding protein (inferred from 100% identity to eco:b1920)

MetaCyc: 100% identical to cystine ABC transporter periplasmic binding protein (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-290 [EC: 7.4.2.12]; 7.4.2.12 [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]; 7.4.2.- [EC: 7.4.2.12]

Predicted SEED Role

"Cystine ABC transporter, periplasmic cystine-binding protein FliY"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.4.2.12

Protein Sequence (266 amino acids)

>ECOLIN_RS10935 cystine ABC transporter substrate-binding protein (Escherichia coli Nissle 1917)
MKLAHLGRQALMGVMAVALVAGMSVKSFADEGLLNKVKERGTLLVGLEGTYPPFSFQGDD
GKLTGFEVEFAQQLAKHLGVEASLKPTKWDGMLASLDSKRIDVVINQVTISDERKKKYDF
STPYTISGIQALVKKGNEGTIKTADDLKGKKVGVGLGTNYEEWLRQNVQGVDVRTYDDDP
TKYQDLRVGRIDAILVDRLAALDLVKKTNDTLAVTGEAFSRQESGVALRKGNEDLLKAVN
DAIAEMQKDGTLQALSEKWFGADVTK