Protein Info for ECOLIN_RS10500 in Escherichia coli Nissle 1917

Annotation: ClpP-like prohead protease/major capsid protein fusion protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 671 transmembrane" amino acids 98 to 108 (11 residues), see Phobius details PF00574: CLP_protease" amino acids 19 to 191 (173 residues), 136.7 bits, see alignment E=1.2e-43 PF01972: SDH_sah" amino acids 52 to 121 (70 residues), 25.8 bits, see alignment E=7.8e-10

Best Hits

KEGG orthology group: None (inferred from 88% identity to esc:Entcl_1867)

Predicted SEED Role

"Prophage Clp protease-like protein" in subsystem cAMP signaling in bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (671 amino acids)

>ECOLIN_RS10500 ClpP-like prohead protease/major capsid protein fusion protein (Escherichia coli Nissle 1917)
MPKPKNRARHRPKASAKSNSWFRMQASNNSEADIFIYDEIGYWGVTAKQFVNDLRALGDV
THINLYINSPGGDVFDGIAIYNALKHHGAAITVHIDGLAASMASVIAMVGNPVIMPENTM
MMIHKPWGFAGGDASDMRDYADLLDKVESVLIPAYAQKTGKSTEEIAVMLEDETWMNGSE
CLELGFADQVTPSLQAMACIHSKRIEEFEKMPKSIRNMITPPRNTTQRDPVITQPQAPQA
KTDPAPDENAIRAQVLAEQKTRVNAIGDLFAMFGNKHMELQNQCVADPDCSVDKAKDLLL
AELGKTATPSNKTTQPHIHAGNGNFVADGIRQALMARAGFEGQERDNVYNGMTLREYARM
ALTEKGIGVASYNPMQMVGLALTHSTSDFGNILLDVANKALIQGWDEAQETFEQWTKKGQ
LSDFKTAHRVGMGGFPSLRQVREGAEYKYITTSDKGETIALATYGEIFSVTRQAIINDDL
NQLTDVPMKMGRAAKATIGDLVYAILTKNPKLSDGKALFHADHKNLSSGAISVASLDESR
KLMRLQKEGERTLNIRPAYMLVPVALETLANQTIKSASVKGADINAGIVNPIQNFAEVIA
EPRLDEADAKAWYLAAAKGTDTIEVAYLNGVDTPYIDQQEGFTTDGIATKVRIDAGVAPL
DYRGMTKSSGQ