Protein Info for ECOLIN_RS08805 in Escherichia coli Nissle 1917

Annotation: peptidyl-dipeptidase Dcp

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 681 transmembrane" amino acids 600 to 615 (16 residues), see Phobius details PF01432: Peptidase_M3" amino acids 230 to 678 (449 residues), 502.6 bits, see alignment E=8.1e-155

Best Hits

Swiss-Prot: 98% identical to DCP_ECOLI: Dipeptidyl carboxypeptidase (dcp) from Escherichia coli (strain K12)

KEGG orthology group: K01284, peptidyl-dipeptidase Dcp [EC: 3.4.15.5] (inferred from 100% identity to ecc:c1964)

MetaCyc: 98% identical to peptidyl-dipeptidase Dcp (Escherichia coli K-12 substr. MG1655)
Peptidyl-dipeptidase Dcp. [EC: 3.4.15.5]

Predicted SEED Role

"Dipeptidyl carboxypeptidase Dcp (EC 3.4.15.5)" in subsystem Protein degradation (EC 3.4.15.5)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.15.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (681 amino acids)

>ECOLIN_RS08805 peptidyl-dipeptidase Dcp (Escherichia coli Nissle 1917)
MTTMNPFLVQSTLPYLAPHFDQIANHHYRPAFDEGIQQKRAEIAAIALNPQTPDFNNTIL
ALEQSGELLTRVTSVFFAMTAAHTNDELQRLDEQFSAELAELANDIYLNGELFARVDAVW
QRRESLGLDSESIRLVEVIHQRFVLAGAKLEQADKAKLKVLNTEAATLTSQFNQRLLAAN
KSGGLVVNDIAQLAGMSEQEIVLAAEAAREKGLDNNWLIPLLNTTQQPALAELRDRATRE
KLFTAGWTRAEKNDANDTRAIIQRLVEIRAQQAKLLGFPHYAAWKIADQMAKTPEAALNF
MREIVPAARQRASDELASIQAIIDKQQGGFSAQSWDWAFYAEQVRREKFDLDEAQLKPYF
ELNTVLNEGVFWTANQLFGIKFVERFDIPVYHPDVRVWEIFDHNGVGLALFYGDFFARDS
KSGGAWMGNFVEQSTLNETHPVIYNVCNYQKPAAGEPALLLWDDVITLFHEFGHTLHGLF
ARQRYATLSGTNTPRDFVEFPSQINEHWATHPQVFARYARHYQSGAAMPDELQQKMRNAS
LFNKGYEMSELLSAALLDMRWHCLEENEAMQDVDDFELWALVAENMDLPAIPPRYRSSYF
AHIFGGGYAAGYYAYLWTQMLADDGYQWFVEQGGLTRENGRRFREAILSRGNSEDLERLY
RQWRGKAPQIMPMLQHRGLNV