Protein Info for ECOLIN_RS03220 in Escherichia coli Nissle 1917

Annotation: enterobactin non-ribosomal peptide synthetase EntF

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1293 PF00668: Condensation" amino acids 2 to 442 (441 residues), 366.6 bits, see alignment E=3.7e-113 PF00501: AMP-binding" amino acids 462 to 814 (353 residues), 302 bits, see alignment E=1.2e-93 TIGR01733: amino acid adenylation domain" amino acids 482 to 886 (405 residues), 421.2 bits, see alignment E=1.9e-130 PF00550: PP-binding" amino acids 980 to 1040 (61 residues), 50.4 bits, see alignment 4.2e-17 PF00975: Thioesterase" amino acids 1067 to 1281 (215 residues), 195.5 bits, see alignment E=3.1e-61

Best Hits

Swiss-Prot: 97% identical to ENTF_ECOLI: Enterobactin synthase component F (entF) from Escherichia coli (strain K12)

KEGG orthology group: K02364, enterobactin synthetase component F [EC: 2.7.7.-] (inferred from 100% identity to ecc:c0673)

MetaCyc: 97% identical to apo-serine activating enzyme (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Enterobactin synthetase component F, serine activating enzyme (EC 2.7.7.-)" in subsystem Siderophore Enterobactin (EC 2.7.7.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.-

Use Curated BLAST to search for 2.7.7.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1293 amino acids)

>ECOLIN_RS03220 enterobactin non-ribosomal peptide synthetase EntF (Escherichia coli Nissle 1917)
MSQHLPLVAAQPGIWMAEKLSDLPSAWSVAHYVELTGEVDAPLLARAVVAGLAQADTLRM
RFTEDNGEVWQWVDDAQTFELPEIIDLRTNIDPHGTARALMQADLQQDLRVDSGKPLVFH
QLIQVADNRWYWYQRYHHLLVDGFSFPAITRQIANIYCALLRGEPTPASPFTPFADVVEE
YQQYRESEAWQRDAAFWAEQRRQLPPPASLSPAPLPGRSASADILRLKLEFTNGEFRQLA
TQLSGVQRTDLALALAALWLGRLCNRMDYAAGFIFMRRLGSAALTATGPVLNVLPLGIHI
AAQETLPQLATRLAAQLKKMRRHQRYDAEQIVRDSGRAAGEEPLFGPVLNIKVFDYQLDI
PGVQAQTHTLATGPVNDLELALFPDEHGDLSIEILANKQRYDEPTLIQHAERLKMLIAQF
AANPSLLCGDVDIMLPGEYAQLAQINATQVEIPETTLSALVAEQAAKTPDAPALADARYQ
FSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEAGAAWLPLDTGYP
DDRLKMMLEDARPSLLITTDDQLPRFSDIPNLTSLCYNAPLTPQGSAPLQLSQPHHTAYI
IFTSGSTGRPKGVMVGQQAIVNRLLWMQNHYPLTGEDVVAQKTPCSFDVSVWEFFWPFIA
GAKLVMAEPEAHRDPLAMQHFFADYGVTTTHFVPSMLAAFVASLTPQTARQSCATLKQVF
CSGEALPADLCREWQQLTGAPLHNLYGPTEAAVDVSWYPAFGEELAEVRGSSVPIGYPVW
NTGLRILDAMMHPVPPGVAGDLYLTGIQLAQGYLGRPDLTASRFIADPFAPGERMYRTGD
VARWLDNGAVEYLGRSDDQLKIRGQRIELGEIDRVMQALPDVEQAVTHACVINQAAATGG
DARQLVGYLVSQSGLPLDTSALQAQLRETLPPHMVPVVLLQLPQLPLSANGKLDRKALPL
PELKAQTPGRVPKAGSETIIAAAFSSLLGCDVQDADADFFALGGHSLLAMKLAAQLSRQF
ARQVTPGQVMVASTVAKLATIIDGEEDSTQRMGFETILPLREGNGPTLFCFHPASGFAWQ
FSVLSRYLDPQWSIIGIQSPRPHGPMQTAANLDEVCEAHLATLLEQQPHGPYYLLGYSLG
GTLAQGIAARLRARGEQVAFLGLLDTWPPETQNWQEKEANGLDPEVLAEINREREAFLAA
QQGSTSTELFTTIEGNYADAVRLLTTAHSVPFDGKATLFVAERTLQEGMTPEQAWAPWIA
ELDIYRQDCAHVDIISPEYFKEIGPLINTQINN