Protein Info for ECOLIN_RS02100 in Escherichia coli Nissle 1917

Annotation: acyl-CoA synthetase FdrA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 515 PF02629: CoA_binding" amino acids 189 to 282 (94 residues), 42.1 bits, see alignment E=1.3e-14 PF00549: Ligase_CoA" amino acids 346 to 502 (157 residues), 107 bits, see alignment E=8e-35

Best Hits

Swiss-Prot: 98% identical to YAHF_ECOLI: Uncharacterized protein YahF (yahF) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to ecc:c0441)

Predicted SEED Role

"Putative oxidoreductase subunit"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (515 amino acids)

>ECOLIN_RS02100 acyl-CoA synthetase FdrA (Escherichia coli Nissle 1917)
MSVKIVIKPNTYFDSVSLMSISTRANKLDGVEQAFVAMATEMNKGVLKNLGLLTPELEQA
KNGDLMIVINGKSGVDNEQLLAEIEELFNTKAQSGSHEARYATIASAKKYIPESNLAVIS
VNGLFAAREARQALQNDLNVMLFSDNVSVEDELALKQLAHEKGLLMMGPDCGTAIINGAA
LCFGNAVRRGNIGIVGASGTGSQELSVRIYEFGGGVSQLIGTGGRDLSEKIGGLMMLDAI
GMLENDPQTEIIVLISKPPAPAVARKVLERARACRKPVVACFLGRGETPVDEQGLQFARG
SKEAALKAVMLSGVKQEHLDLHTLNQPLIADVRARLQPQQKYIRGLFCGGTLCDETLFAV
MEKHGDVYSNIQPDPEFRLQDINRSIKHTFLDFGDDDFTNGKPHPMIDPTNRISRLIEEA
RDPEVAVIVMDFVLGFGSHEDPVGSTIEAIKEAKAIAAAEGRELIILAYVLGTDLDTPSL
EQQSQMLLDAGVILASSSTNTGLLAREFICKGEEA