Protein Info for Dsui_3176 in Dechlorosoma suillum PS

Annotation: RND family efflux transporter, MFP subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 transmembrane" amino acids 35 to 53 (19 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 62 to 343 (282 residues), 141.3 bits, see alignment E=1.8e-45 PF16576: HlyD_D23" amino acids 83 to 322 (240 residues), 61.2 bits, see alignment E=1.4e-20 PF13533: Biotin_lipoyl_2" amino acids 86 to 130 (45 residues), 36.2 bits, see alignment 6e-13 PF13437: HlyD_3" amino acids 212 to 319 (108 residues), 49.5 bits, see alignment E=9.6e-17

Best Hits

KEGG orthology group: K02005, HlyD family secretion protein (inferred from 72% identity to dar:Daro_3918)

Predicted SEED Role

"Macrolide-specific efflux protein MacA" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QIP8 at UniProt or InterPro

Protein Sequence (428 amino acids)

>Dsui_3176 RND family efflux transporter, MFP subunit (Dechlorosoma suillum PS)
MTSPQDNPTGALQDLLKKAAGSGARPLWQRYPKRFLAGGAIAVLALALLLSGGKKSQGQF
LTETVDSGPLVVTVSASGTLAPTKSVDVGSELSGTLESVLVQENEQVKKGQLLAQLDISK
LKDQVVKSQAAVAAAEASVAQAVATVAEARASLSRMRQVAELSGGKVPAKTELETAEATL
LRAQANEASARATVTQARATLKSDETNIAKATIRSPVDGVVLTRKVEPGQTVVAAMTTPV
LFSLAEDLTQMELQVKVDEADVGSVQVGQQASFTVSAWSGRKFPAQIQRVGIGSTTTDNV
VTYKTVLKVANNDLALRPGMTATAEIITASRDKALLVPNAALRFTPPQAAGGDQRSFLSR
LMPGPPREPEKKRKDNGAAATQVWVLQEGQPVAVAVTPGVSNGRYTEILGGDLQPGMAVI
TEYQEMRP