Protein Info for Dsui_3104 in Dechlorosoma suillum PS

Annotation: PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 833 PF13188: PAS_8" amino acids 161 to 211 (51 residues), 17.1 bits, see alignment 1.5e-06 amino acids 285 to 335 (51 residues), 30.9 bits, see alignment 6.6e-11 TIGR00229: PAS domain S-box protein" amino acids 161 to 282 (122 residues), 72.7 bits, see alignment E=2.9e-24 amino acids 280 to 403 (124 residues), 63.7 bits, see alignment E=1.8e-21 PF00989: PAS" amino acids 161 to 272 (112 residues), 53.5 bits, see alignment E=8.1e-18 amino acids 287 to 394 (108 residues), 35.3 bits, see alignment E=3.5e-12 PF08448: PAS_4" amino acids 164 to 275 (112 residues), 35.5 bits, see alignment E=3.7e-12 amino acids 289 to 399 (111 residues), 29.4 bits, see alignment E=2.9e-10 PF13426: PAS_9" amino acids 169 to 273 (105 residues), 55.2 bits, see alignment E=2.8e-18 amino acids 294 to 396 (103 residues), 45.1 bits, see alignment E=3.7e-15 PF08447: PAS_3" amino acids 181 to 268 (88 residues), 33.5 bits, see alignment E=1.4e-11 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 406 to 562 (157 residues), 144.4 bits, see alignment E=2.7e-46 PF00990: GGDEF" amino acids 408 to 561 (154 residues), 167.8 bits, see alignment E=5.9e-53 PF00563: EAL" amino acids 585 to 818 (234 residues), 266.9 bits, see alignment E=5.2e-83

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QI35 at UniProt or InterPro

Protein Sequence (833 amino acids)

>Dsui_3104 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein (Dechlorosoma suillum PS)
MAPDQGNSFLPHLGGGATDFELAGQLCYALLLREGEIPVAQLEAMCRSAMASPEGTLYLA
NGDGTLELPASAGPWQALLEEARRSGTVATRPDALACPLTFRDMLLGLLAVGGKAEGYSA
LEHRRFGDLAALLAGALHARQAFNLRQEDLARMEAKVEEQSQILDHIHDSVITMDLSGYI
MGWNKGAERLFGYTAAEAVGRHILFLYADDGSETLEEEDDLFYNAFLDHGRREFEVRRRK
KSGEVFWASVSLSLSRNEAGEPAGLIGYLVDITNQLEREEKLRLHAKIFEHNSEAVIVTD
AMQRVLSVNKAFCDITGFSEAEVRMSLPALLQPTRDDPNLAAEIQVALASSGAWQGELWD
RRKNGDTYPVWVSISSVKNTRGILSHYFLVFSDISERKEAERQIYRLAYYDALTGLPNRS
LLFSLLEQALIEAQRNQTHGAVLFVDLDRFKTINDSFGHAPADALLKEVARRLQETLRAE
DVVARLGGDEFIVALFDITKREHAALVGQKILDALAEPFQIVHHEVLLTASIGIAVFPDD
GRDAETLLRNADTAMYRVKQTSGGPLFYSQEMNLRSLERLKLEGALRKAVERQEFRLYYQ
PQVELATGRIVGAEALIRWHHPEQGMIPPTAFIPLAEETGLIVSIGAWVLDAACRQGRLW
REAGYEDLTIAVNLSPRQFRPGLSQLVNETLERHAFPGENLELEITEGMLMHNSEAVIQM
LEDFHQAGVRLALDDFGTGYSSLAYLKKFPIDNLKIDRSFVSGIPHDGDDSAIAKAIISM
AKNLRLLVIAEGVETEEQLDFLRAAGCDEIQGYLFSPPVPVEDFQLLLERNNG