Protein Info for Dsui_2991 in Dechlorosoma suillum PS

Annotation: PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 807 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details transmembrane" amino acids 327 to 349 (23 residues), see Phobius details PF09084: NMT1" amino acids 42 to 249 (208 residues), 168.5 bits, see alignment E=7.2e-53 TIGR00229: PAS domain S-box protein" amino acids 367 to 493 (127 residues), 96.4 bits, see alignment E=1.3e-31 amino acids 494 to 616 (123 residues), 44.9 bits, see alignment E=1.2e-15 PF13188: PAS_8" amino acids 371 to 425 (55 residues), 32.4 bits, see alignment 2.2e-11 PF00989: PAS" amino acids 371 to 472 (102 residues), 51.9 bits, see alignment E=2.5e-17 amino acids 499 to 597 (99 residues), 40.3 bits, see alignment E=1e-13 PF08448: PAS_4" amino acids 377 to 488 (112 residues), 58.4 bits, see alignment E=2.7e-19 amino acids 505 to 596 (92 residues), 23.5 bits, see alignment E=2e-08 PF13426: PAS_9" amino acids 383 to 485 (103 residues), 29.7 bits, see alignment E=2.2e-10 amino acids 510 to 608 (99 residues), 26.3 bits, see alignment E=2.5e-09 PF08447: PAS_3" amino acids 394 to 478 (85 residues), 34.1 bits, see alignment E=9.2e-12 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 637 to 802 (166 residues), 180 bits, see alignment E=3e-57 PF00990: GGDEF" amino acids 641 to 798 (158 residues), 161.7 bits, see alignment E=4.6e-51

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QGZ3 at UniProt or InterPro

Protein Sequence (807 amino acids)

>Dsui_2991 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein (Dechlorosoma suillum PS)
MPPGAAHRRLLGHLLAALYLLLAAGAAGALESVTLQLKWQHQFQFAGYYMAQARGYYREA
GLEVRIVEGRADTDPVAEVLAGRAQYGIGASELLLERSRGKPVVALAAVFQHSPLVLLAR
AGGPIRRPADLEGRRLMLLPTEAELFAFLRREQVKEERLQRVPHSFSAADLMAGRVDAVS
GYLTDETYELEKAGFPYLSFSPRAANIDFYGDTLFTAEAHAVAHPQQVEAFRRASLQGWA
AALADPDAAAREILQHYSTRHSLEHLLFEAERMRPLIEPTLVELGHMSPARWRRIGDTYA
ELGMMPRDYAVETLLYRPAGPQPLPPWAWGTLLLAALALLAALYIHRLYGRLQGQMRQRD
SSERNLRASREHLARIFETAPLAAIVYDQEARVLEWNHRAEEIFGWRREEMLGRSFFEHM
VPEEARQQVQGIVDSIFRGPEIQYSLNRNLTRDGRAILCEWSNAILRDEAGGPPSVIALA
ADVTERERVRAALQDSEQRYRTLLETAPFPVVITRLRDSLVTYINQRAATCFQVPQEDAV
GRHAPDYWVDMGQRQRLIEELRQKQVVTDMEVRLRDAAGQPFWALLSARILLEEQEPLAF
VSFNNINERKAAEEALQALNGELAYRLQEINLLQARLQEQATRDALTGLYNRRYLDETLE
REVARAQREGYPLAVALLDIDHFKQLNDTYGHRAGDEMLRQLGHFLQARARSGDVPCRYG
GEEFLLVLPGVDLETARQRAEEWRAGFAGLTVNFGSLALQATLSVGVACYPGHGKSADAL
VDAADAALYRAKAGGRNRVEVAGAVEE