Protein Info for Dsui_2978 in Dechlorosoma suillum PS

Annotation: dihydroorotate dehydrogenase, subfamily 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01036: dihydroorotate dehydrogenase (fumarate)
  • amino acids 12 to 349 (338 residues), 438.2 bits, E=9e-136
• PF01180: DHO_dh
  • amino acids 56 to 348 (293 residues), 289.5 bits, E=1.4e-90

Best Hits

Swiss-Prot: 73% identical to PYRD_DECAR: Dihydroorotate dehydrogenase (quinone) (pyrD) from Dechloromonas aromatica (strain RCB)

KEGG orthology group: K00226, dihydroorotate dehydrogenase (fumarate) [EC: 1.3.98.1] (inferred from 73% identity to dar:Daro_1164)

MetaCyc: 55% identical to dihydroorotate dehydrogenase, type 2 (Escherichia coli K-12 substr. MG1655)
Dihydroorotate dehydrogenase. [EC: 1.3.5.2]; 1.3.5.2 [EC: 1.3.5.2]; 1.3.5.2 [EC: 1.3.5.2]

Predicted SEED Role

"Dihydroorotate dehydrogenase (EC 1.3.3.1)" in subsystem De Novo Pyrimidine Synthesis (EC 1.3.3.1)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (18/18 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (9/9 steps found)
• UMP biosynthesis I (6/6 steps found)
• UMP biosynthesis II (6/6 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.3.1 or 1.3.5.2 or 1.3.98.1

Sequence Analysis Tools

See G8QGY1 at UniProt or InterPro

Protein Sequence (353 amino acids)

>Dsui_2978 dihydroorotate dehydrogenase, subfamily 2 (Dechlorosoma suillum PS)
MVHCGKIAPMLYSLARKIFFSLDAEKAHGIGLNGLAALHAAGLSCLMGKKAPECPVEVMG
LRFPNPVGLAAGLDKNGECIDGMAAMGFGFLEVGTVTPRPQPGNPKPRLFRIEEKQAIIN
RMGFNNEGVDHLLQNVALAQFPKCGGILGINIGKNFDTPIEKAADDYLICLEKVYAAASY
VTVNISSPNTKNLRDLQRDDALDDLLRQLKAAQARLAEKHGKHTPLALKIAPDLDDAQIQ
AIADLLRQHRMDGVIATNTTLSRNGVEGCRYGNEAGGLSGAPVRDLSTQVIRKLATALQG
EVPIIGVGGILSGADAAEKIEAGAKLVQIYSGFIYRGPDLVREAAETLCRMGR