Protein Info for Dsui_2737 in Dechlorosoma suillum PS

Annotation: glycine dehydrogenase, decarboxylating

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 966 transmembrane" amino acids 761 to 773 (13 residues), see Phobius details TIGR00461: glycine dehydrogenase" amino acids 21 to 957 (937 residues), 1503 bits, see alignment E=0 PF02347: GDC-P" amino acids 21 to 442 (422 residues), 579.7 bits, see alignment E=3.7e-178 amino acids 478 to 732 (255 residues), 33.2 bits, see alignment E=2.9e-12 PF21478: GcvP2_C" amino acids 785 to 906 (122 residues), 204.6 bits, see alignment E=3.5e-65

Best Hits

Swiss-Prot: 65% identical to GCSP2_PSEPF: Glycine dehydrogenase (decarboxylating) 2 (gcvP2) from Pseudomonas fluorescens (strain Pf0-1)

KEGG orthology group: K00281, glycine dehydrogenase [EC: 1.4.4.2] (inferred from 76% identity to app:CAP2UW1_1958)

Predicted SEED Role

"Glycine dehydrogenase [decarboxylating] (glycine cleavage system P protein) (EC 1.4.4.2)" in subsystem Glycine and Serine Utilization or Glycine cleavage system or Photorespiration (oxidative C2 cycle) (EC 1.4.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.4.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QPX7 at UniProt or InterPro

Protein Sequence (966 amino acids)

>Dsui_2737 glycine dehydrogenase, decarboxylating (Dechlorosoma suillum PS)
MSDTLPQSLSALEQKDEFIARHIGPCASEMSQMLAAIGAASLDQLVDQTVPAAIRFPADL
PLPAPRREHEALADLKALAGRNVVKKSLIGQGYHETLTPKVILRNVLENPGWYTAYTPYQ
AEIAQGRLEALLNYQQVIIDLTGLELANASLLDEATAAAEAMTMARRVSKSGSNRFFVDA
ACFPQTIDVVKTRAAYFGFELIFGPVEEAATVEVFGALLQYPNDKGEVQDLTATIAALKA
KGAVTAVACDLMALVLLKSPGAMGADMALGSSQRFGIPMGFGGPHAAFFACKDEHKRSVA
GRIIGVSVDARGNKALRMALQTREQHIRREKANSNICTSQVLLANMAGMYAVYHGPEGLK
TIARRIHRLAAILATGLAKAGIKQLNACYFDTLQLDLGAKALTVYQAAQNAGYNLRLIEG
GRLGIALNEKTTREDVATLLQLIAGVKVDIEALDAQVAAADPALPAELLRTDAILSHPVF
NTHHTEHEMLRYLKKLQNKDLALDHSMISLGSCTMKLNATSEMIPVTWPEFGDIHPFAPL
DQAQGYLEMIEQLAEWLKTVTGFDAVCMQPNSGAQGEYAGLVAIRRYQEANGQGQRDICL
IPKSAHGTNPATAQMAGLQVVVVDCDDNGNVDVADLKAKAEQHAAKLSCLMLTYPSTHGV
FEEAVKDICDIVHANGGQVYMDGANLNAQVGLTAPGFIGADVSHMNLHKTFAIPHGGGGP
GMGPIGLKAHLAPYMADHAVQATGPAERKHKGQGAVSAAPFGSASILPISWMYIAMLGGK
GVKTATQVAILNANYVAARLQEHYPVLYRGKNGRVAHECILDIRPIKAATGIAEIDIAKR
LMDYGFHAPTVSFPVAGTIMVEPTESESKAELDRFIDALIAIRNEIRKVEAGQWPADNNP
LKHAPHTQKDLADEVWSRPYSRQEACYPLAWVAENKFWPSVNRIDDVYGDRNLFCACAPV
EDYQHG