Protein Info for Dsui_2385 in Dechlorosoma suillum PS

Annotation: transcription-repair coupling factor Mfd

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1198 PF17757: UvrB_inter" amino acids 189 to 276 (88 residues), 81.7 bits, see alignment 1.2e-26 TIGR00580: transcription-repair coupling factor" amino acids 206 to 1133 (928 residues), 1060.4 bits, see alignment E=0 PF21132: MFD_D3" amino acids 437 to 503 (67 residues), 62 bits, see alignment 1.5e-20 PF02559: CarD_TRCF_RID" amino acids 532 to 588 (57 residues), 66.4 bits, see alignment 6.6e-22 PF04851: ResIII" amino acids 657 to 813 (157 residues), 45 bits, see alignment E=3.9e-15 PF00270: DEAD" amino acids 657 to 818 (162 residues), 88 bits, see alignment E=2.2e-28 PF00271: Helicase_C" amino acids 857 to 961 (105 residues), 61.2 bits, see alignment E=3.9e-20 PF03461: TRCF" amino acids 1061 to 1152 (92 residues), 95.6 bits, see alignment 6.6e-31

Best Hits

KEGG orthology group: K03723, transcription-repair coupling factor (superfamily II helicase) [EC: 3.6.4.-] (inferred from 77% identity to app:CAP2UW1_1080)

Predicted SEED Role

"Transcription-repair coupling factor" in subsystem DNA-replication or Transcription factors bacterial

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.-

Use Curated BLAST to search for 3.6.4.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QLV5 at UniProt or InterPro

Protein Sequence (1198 amino acids)

>Dsui_2385 transcription-repair coupling factor Mfd (Dechlorosoma suillum PS)
MNLPRLHCGASPAPASANGSAPAGPAPLGYNPASPACLIYLLVSASTSPALPELPPEISR
ALAQLPRSGERLHLPPLAGSADALALARLGSQARSQKRLLAVLTASPADAQRLLEEIPWF
APDLKVRLLPDWETLPYDNFSPHHDLVSERLATLYAVSRGECEVLLVPATTAVYRLTPPS
YLAAYTFFLKKGEKLDAEQFRSQLTLAGYTHVTQVVSPGEYSIRGGLVDLFPMGSALPYR
IDLFDEEIETLRTFDADTQRSLYPVPEIRLLPAREFPLDDGGRTRFRQRFREVFEGDPAK
SGIYKDVSNGVPSAGIEYWLPLFFEETATLFDYLPKDAVLCQHRDVALALQDFWRDTQSR
YNMLAGDKARPLLPPAELFLSEEQFFVAAKDYAKLILGTPAEGMPPLATAVPTVAVERRA
EDPLTALKQFIAGRQGRRTLLLAESAGRRETLQQLLLEHGLKPAASADFAAFLGGDAPLA
LGVAPLQSGFCLDGLAIITETELYAGSPNRRSRQNAQRRASMDNWLRDLTELKVGDPVVH
ESHGIGRYMGLLHLDLGEGDTEFLELHYANEAKLYVPVSQLHVISRYSGNEPDAAPLHSL
GSGQWEKAKKKAAEQARDTAAELLALYAARAARQGHAFAFTENDYEAFADGFGFEETEDQ
ATAIAAVIEDMKSGKPMDRLVCGDVGFGKTEVALRAAFVAVAGGKQVAVLCPTTLLCEQH
YQTFKDRFADWPVQIAELSRFKTAKETAQAMKDLEAGKIDIVIGTHKLLSKEMKFDRLGL
VMIDEEHRFGVRQKEALKALRAEVDVLTLTATPIPRTLAMSLEGLRDFSVIATAPQKRLA
IKTFVAKFSDGIIREAVLRELKRGGQVYFLHNEVDTIDNMREKLQSLVPEARIVVGHGQM
NERELERVMRDFTQQRANLLLCTTIIETGIDNPHANTILINRAEKFGLAQLHQLRGRVGR
SHHQAYSYLLVQDEKALTKQAKQRLEAIQHMEELGAGFYLAMHDLEIRGAGEVLGENQSG
EMQEVGFNLYTEMLNRAVAALKQGREPDLTQPLGVTTEINLHAPALLPDAYAPDVHERLT
LYKRLSNCETEEDINALQEELIDRFGELPPQGQCLLATHRLRLLARPLGIVKLDATASQL
TVQFCPNPPIEPIRIIELIQKNRHFKLAGQDKLAVVRHMPTLKERVDAVKDLFRQLGA