Protein Info for Dsui_2161 in Dechlorosoma suillum PS

Annotation: ATP-dependent chaperone ClpB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 861 TIGR03346: ATP-dependent chaperone protein ClpB" amino acids 6 to 854 (849 residues), 1435.7 bits, see alignment E=0 PF02861: Clp_N" amino acids 17 to 68 (52 residues), 53.8 bits, see alignment 1.2e-17 amino acids 95 to 145 (51 residues), 34.8 bits, see alignment 1e-11 PF00004: AAA" amino acids 203 to 335 (133 residues), 48.5 bits, see alignment E=8.5e-16 amino acids 605 to 723 (119 residues), 40.1 bits, see alignment E=3.4e-13 PF17871: AAA_lid_9" amino acids 342 to 440 (99 residues), 119.3 bits, see alignment E=4.5e-38 PF07724: AAA_2" amino acids 599 to 761 (163 residues), 237 bits, see alignment E=8.5e-74 PF00158: Sigma54_activat" amino acids 603 to 730 (128 residues), 25.7 bits, see alignment E=5.8e-09 PF07728: AAA_5" amino acids 604 to 725 (122 residues), 50.9 bits, see alignment E=1.2e-16 PF10431: ClpB_D2-small" amino acids 768 to 848 (81 residues), 90.9 bits, see alignment E=2.9e-29

Best Hits

Swiss-Prot: 79% identical to CLPB_NITEU: Chaperone protein ClpB (clpB) from Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)

KEGG orthology group: K03695, ATP-dependent Clp protease ATP-binding subunit ClpB (inferred from 84% identity to azo:azo1566)

MetaCyc: 67% identical to protein disaggregase ClpB (Escherichia coli K-12 substr. MG1655)
RXN185E-10

Predicted SEED Role

"ClpB protein" in subsystem Protein chaperones or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QJQ3 at UniProt or InterPro

Protein Sequence (861 amino acids)

>Dsui_2161 ATP-dependent chaperone ClpB (Dechlorosoma suillum PS)
MRFDKFTTKFQQALADAQSLAIGADNQFIDPSHLLLALLNQDDGGTASLLARAGVNVPPL
RTALEQAIARLPKVEGHGGDVSIGRDLTNLLNLTDKEAQKRGDQFIASEMFLLALTGDKG
ETSRIAKQYGLEKKPLEAAIDAVRGGQGVDSQEAEGQRESLKKYCVDLTERAAQGKLDPV
IGRDDEIRRAIQILQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNDEVPETLKGKKVLVL
DMAGLLAGAKYRGEFEERLKAVLNDIAKDEGRIILFIDEIHTMVGAGKAEGAIDAGNMLK
PALARGELHCIGATTLDEYRKYIEKDAALERRFQKVLVDEPSVEATIAILRGLQEKYELH
HGVDITDPAIVAAAELSHRYITDRFLPDKAIDLIDEAAARIKMEIDSKPEVMDKLDRRII
QLKIEREAVKKEKDEASKKRFGLIEDEIAKLQKEYSDLEEVWKAEKAQVHGAAHVKEEID
KIKAEIARLQREGKLEKVAELQYGKLPQLEAQLKVAEKASEGGQQQNKLLRTQVGAEEIA
EVVSRATGIPVSKMMQGERDKLLKMEDRLHQRVVGQDEAVRLVSDAIRRSRAGLSDPNRP
YGSFLFLGPTGVGKTELCKALAEFLFDSEDHLIRIDMSEFMEKHSVARLIGAPPGYVGYE
EGGTLTEAVRRKPYSVILLDEVEKAHPDVFNVLLQVLDDGRMTDGQGRTVDFKNTVIVMT
SNLGSQMIQQMAGDDYQLIKLAVMGEVKSYFRPEFINRIDEAVVFHSLDEKNIRNIARIQ
LGYLEKRVAQLEMRLEVADSALDELAKAGFDPIFGARPLKRAIQQHIENPLAKQILEGNF
GPKDTILVSCDEGGVMRFAKG