Protein Info for Dsui_1565 in Dechlorosoma suillum PS

Annotation: diguanylate cyclase (GGDEF) domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 847 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 171 to 193 (23 residues), see Phobius details TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 426 to 591 (166 residues), 176.9 bits, see alignment E=1.3e-56 PF00990: GGDEF" amino acids 430 to 588 (159 residues), 155.3 bits, see alignment E=1.2e-49 PF00563: EAL" amino acids 611 to 839 (229 residues), 218.5 bits, see alignment E=9e-69

Best Hits

KEGG orthology group: None (inferred from 58% identity to azo:azo1476)

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QPP5 at UniProt or InterPro

Protein Sequence (847 amino acids)

>Dsui_1565 diguanylate cyclase (GGDEF) domain-containing protein (Dechlorosoma suillum PS)
MKIRTFVLATSILVGLLFFGGSYWAVSRSFDSTVRDHAREGANTMARMAFVSMYELMSTG
WRRDQVEKFLQGMRDATRGSNATVEIYRGPKVEALFGAIEQPPLDELLRQGFSAGKPQES
MQGSFIRFIYPLQAENRCLRCHDNAAVGDVLGLIEVRQNVGGLVDQARAEFSWSLAILMP
LGLLLALLAVWWVNHRLEGALRHVEEGVAGVNAVSDLRKLELRGSRPGFAELTRIVCAVE
ELVAKLRAVAVDKDMLKFEIGLLEKFVITSDIIRDWTEYVNHLVVDINKVMNAHVLFSIF
QIDDELFDLEIFWYREPSAATKQRVESHIREVLKQNPRFSVITSFTINHHVAKPGGEKVE
LAEEEVQLRVKSFFVDTPKIGGIVGIGVQADELEDDTRHLVLDSVLSTLLNVVGSVKAIY
KYTKDLEYYATRDPLTDLFNQRVFWEMIGYEIDRSSRHDEHFGLLLIDLDNFKLVNDNYG
HAVGDKFLQAFAREVRQVLRSGDIFARYGGDEFVVILPEADLEQTSVIAQRILEASRQSS
VTAFNGDVVHGTASIGLAVYPDHATEPKDLFLFADNMMYKAKAEGKERVAIPTADDVMEV
FRDISQKSVTILKAIDERRLIPFFQPILDVQAGVVVGYEVLSRIEVDGEIMRADEFVEIA
EKIGVIHRLDCLVIELALQKLAAEGHEGYIFLNLSPRAMVLNEFARSLRQIVADSGIPPE
RIVFEITERDTVKNLALMERFLNDLKFDGFKLAIDDFGSGFSSFHYLRRFPVDFLKVEGD
FVVNILHSTKDRAFVQSMQSLAHELGIQVIAEFVETGEVLDELKRMGMDMAQGYYIGRPD
REIRKPA