Protein Info for Dsui_1555 in Dechlorosoma suillum PS

Annotation: cation/multidrug efflux pump

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1023 transmembrane" amino acids 12 to 30 (19 residues), see Phobius details amino acids 333 to 352 (20 residues), see Phobius details amino acids 359 to 382 (24 residues), see Phobius details amino acids 388 to 410 (23 residues), see Phobius details amino acids 430 to 450 (21 residues), see Phobius details amino acids 462 to 487 (26 residues), see Phobius details amino acids 525 to 545 (21 residues), see Phobius details amino acids 846 to 865 (20 residues), see Phobius details amino acids 874 to 894 (21 residues), see Phobius details amino acids 901 to 924 (24 residues), see Phobius details amino acids 946 to 965 (20 residues), see Phobius details amino acids 977 to 1002 (26 residues), see Phobius details PF00873: ACR_tran" amino acids 4 to 1003 (1000 residues), 1020.3 bits, see alignment E=0 PF03176: MMPL" amino acids 304 to 491 (188 residues), 41.1 bits, see alignment E=1.2e-14 amino acids 799 to 1007 (209 residues), 30.7 bits, see alignment E=1.6e-11

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 79% identity to app:CAP2UW1_2462)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QP91 at UniProt or InterPro

Protein Sequence (1023 amino acids)

>Dsui_1555 cation/multidrug efflux pump (Dechlorosoma suillum PS)
MLLSDICIRRPVFATVLSLAVMLIGLVSYQRLSVREYPKIDEPVMTVTTTYRGASAEIVE
SQISKPLEDSLAGIEGVDVLTSISRQESSQISVRFRLERNPDSAASDVRDRVSRVRNRLP
DDIDEPVIAKVEADASPVIWLAFSSEKHSPLVVTDIANRVVKPRLQTLPGAADVRVFGER
KFAMRIWLDKDRLAAHQITAQEVEDALRTQNVEVPAGRIESRQREFAVLAQTDLKEPEQF
AAIVVKTVNGYPVRIRDLGRVEIGAAAERTNVRFGGKPAVSLGLIKQSTANPLDLSRALR
AELPKIAAELPDGLKVEIAYDSSVFIDRSIESVFSTIGEAVILVLLIIFFFLRNLRATLI
PLVTIPVSLIGAFALMFVLGFTINTLTLLALVLAIGLVVDDAIVVLENIYRHIEEGMPPI
QASLQGAKEIGFAVVAMTITLAAVYAPVAFMTGRIGKLFIEFALTLAGAVLVSGFVALTL
SPMMCSVLLRHEEKHGKAFVAIENFLNWLNAGYRRILGAALDRRWIVLVGFAAVALACVG
MLKLLKSELSPIEDRGVIFGIFNGPEGATLEYTDKYARQIEKIYAGIPDAANYFVVSGNP
IVSQGSAILRLKDWKERQHSSPEIAKQLLPRFRDIPGVMAFPVTPPSLGQSARERPINFV
IVSSASYQELQATTTKFLAAMAKSPLFLNVDTDLKLNLPQLSVAVNRDKAADLGVPVETV
GRTLETMLGGRQVTRFKRDGEQYDVIVQVSDADRANPRDISDIYVRGKSGEMIPLANLVQ
VDETISPRELNHFGQRRAVTITANLAPGSTLGEGLAAMEGIAGEVQPAGYAVDYNGQSRE
FKTSTASLALTFILALAFIYLVLAAQFESFRDPFIIMLTVPLSMAGALLALLLSGGTLNV
YSQIGLVTLVGLITKHGILIVEFANQLQEQGRNVREAVIEAAELRLRPILMTTGAMVLGA
IPLALARGAGAESRSQIGWVIVGGLLLGTFFTLFVVPTVYTLMARRKGMDRVAAEQARHG
LPT