Protein Info for Dsui_1429 in Dechlorosoma suillum PS

Annotation: PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1158 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 284 to 302 (19 residues), see Phobius details PF00989: PAS" amino acids 364 to 473 (110 residues), 31.1 bits, see alignment E=8.3e-11 amino acids 488 to 593 (106 residues), 33.3 bits, see alignment E=1.7e-11 amino acids 612 to 718 (107 residues), 39.2 bits, see alignment E=2.5e-13 PF13188: PAS_8" amino acids 366 to 407 (42 residues), 18.6 bits, see alignment (E = 5.8e-07) amino acids 488 to 534 (47 residues), 24.6 bits, see alignment (E = 7.3e-09) amino acids 610 to 653 (44 residues), 31.2 bits, see alignment (E = 6.2e-11) TIGR00229: PAS domain S-box protein" amino acids 366 to 482 (117 residues), 45.1 bits, see alignment E=1.1e-15 amino acids 484 to 606 (123 residues), 64.1 bits, see alignment E=1.4e-21 amino acids 612 to 727 (116 residues), 65 bits, see alignment E=7e-22 PF08448: PAS_4" amino acids 369 to 477 (109 residues), 31.7 bits, see alignment E=6.4e-11 amino acids 508 to 601 (94 residues), 34.6 bits, see alignment E=7.7e-12 amino acids 613 to 723 (111 residues), 35.4 bits, see alignment E=4.4e-12 PF13426: PAS_9" amino acids 376 to 473 (98 residues), 26.8 bits, see alignment E=2.2e-09 amino acids 503 to 598 (96 residues), 31.9 bits, see alignment E=5.4e-11 amino acids 618 to 720 (103 residues), 53.8 bits, see alignment E=8e-18 PF08447: PAS_3" amino acids 630 to 714 (85 residues), 32.2 bits, see alignment 4.3e-11 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 730 to 890 (161 residues), 151.6 bits, see alignment E=1.6e-48 PF00990: GGDEF" amino acids 732 to 888 (157 residues), 183.5 bits, see alignment E=1e-57 PF00563: EAL" amino acids 909 to 1144 (236 residues), 268.3 bits, see alignment E=2.1e-83

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QNH9 at UniProt or InterPro

Protein Sequence (1158 amino acids)

>Dsui_1429 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein (Dechlorosoma suillum PS)
MSLKTKMALAITALVVLLVALGSAVQLHLAQAQLKQTVADQQFSLVSRVAEEIDQRIQLN
QASLARTAAAITPAMLGQPEKLQAFLNDKYSLLLLFDDLIVVGRDGRVIADSPVMPERRG
TDVSAFPHVREALEEGRAVVSRPFLGRVTRLPTLAMTAPVLDGEGRVIASLSGTLQILKP
QFLGGLAGRKVGRSGHFVLVTRDRTTLVSRFPERVLQPNAAPGQNPVFDRAIAGFEGSDE
GATSYGQRVLMSFKSVPSTDWVLGALLPVEEAYAPIETGRWGTVYYLLLTALAVAVLAWL
AMRRVLAPLSRLRQHVVEVRQDHARKLADPVLGQDEIGGLAREFYLLLDELGQARDDLGS
RIAEMESIFDASPVVIGVVRDRCLIQANRAFERLFGVSLETALGQTVVGYYPTPEEFADF
GQQLYPAVADGRVAHFLRRFRRADGTLFWANFYARQIDAQQPQRGIIIVIEDVDQARHQE
EVLRESEERYRQMFENNTSIKLLIDAGDGAIVDANPAAADFYGYPLDTLRRMNIAQLNQL
SVEEVRAEMALADQQQRRYFNFRHRLASGEVREVEVHSGPVLLRGRRLLYSIIHDITARR
RAEEQLRLSAKVFEGASEGIVICDRNNRIMSVNRAFVEITGYAEAEVQGRDPRVLNSGRH
DAAFFANLWHHLKTAGTWQGEIWNRRKGGEVYPEWLSITTVRDEAGEVSNYVAVFADVSE
RKRNEEHIRFLAEHDYLTGLPNRSLLHDRLQQAIALAERNSESLALMFIDLDRFKNINDS
LGHQVGDQLLQEVGRRIQACVRSADTVSRPGGDEFIILLPSIETPQDAARVAEKLLESLN
RPYQLGGHELVITASIGIAVFPEDGRDFQTLVKNADAAMYYSKEAGRDSFHFFTPDMNAR
VFERLSLENSLRRALERQEFLLYYQPQVDMPSGRVIGFEALIRWQHPQMGLVSPARFIPV
AEDSGLIVPIGEWVLGEACRQNRAWQEQGMPAVPVAVNISALQFRQPQFEASVERALAES
GLEPAWLELELTESMMLHQGQGATDLLDRLKARGVRLSIDDFGTGYSSLAYLKRLPLDKL
KIDQAFVRDIASDAGGAAITATIIQMAHNLGLSVIAEGVETEAQLEFLQAHDCASAQGFY
FARPMPAADIRAFWDDRR