Protein Info for Dsui_1411 in Dechlorosoma suillum PS

Annotation: histidinol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 435 PF00815: Histidinol_dh" amino acids 29 to 433 (405 residues), 559.7 bits, see alignment E=2.2e-172 TIGR00069: histidinol dehydrogenase" amino acids 39 to 432 (394 residues), 532.2 bits, see alignment E=4.6e-164

Best Hits

Swiss-Prot: 85% identical to HISX_DECAR: Histidinol dehydrogenase (hisD) from Dechloromonas aromatica (strain RCB)

KEGG orthology group: K00013, histidinol dehydrogenase [EC: 1.1.1.23] (inferred from 85% identity to dar:Daro_3387)

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QNG1 at UniProt or InterPro

Protein Sequence (435 amino acids)

>Dsui_1411 histidinol dehydrogenase (Dechlorosoma suillum PS)
MSSVNIKRLNSADADFQQRLDELLAFEGAQDENIEKTVVGILADVKARGDAAVVEYTNRF
DRLSVAGMAALELPKAELQAALDGLPAERRAALEAAAQRIRTYHERQLGAGFTYTEADGT
MLGQMVTPLDRVGLYVPGGKAAYPSSVLMNALPAKVAGVKELIMVVPTPGGEHNALVLAA
ACLAGVDRVFTIGGAQAVAALAYGTETVPQVDKIVGPGNAYVACAKRRVFGIVGIDMVAG
PSEILVLADGSTDPDWVAMDLFSQAEHDELAQSILICPDAAYIEKVQASIDKLLPTMPRR
DVIRTSLENRGALILVRDLEEAVAMANRVAPEHLELSLAEPDAWVEKIHHAGAIFIGPYT
SESLGDYCAGPNHVLPTSGSARFSSPLGVYDFQKRTSLIRVSRAGAQTLGRIAATLADGE
GLPAHAQSARYRLDA