Protein Info for Dsui_1267 in Dechlorosoma suillum PS

Annotation: riboflavin biosynthesis protein RibD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 365 PF00383: dCMP_cyt_deam_1" amino acids 10 to 107 (98 residues), 67.1 bits, see alignment E=1.7e-22 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 14 to 358 (345 residues), 386.4 bits, see alignment E=1.3e-119 PF14437: MafB19-deam" amino acids 33 to 112 (80 residues), 32.7 bits, see alignment E=9.5e-12 TIGR00227: riboflavin-specific deaminase C-terminal domain" amino acids 153 to 362 (210 residues), 191 bits, see alignment E=2.1e-60 PF01872: RibD_C" amino acids 154 to 356 (203 residues), 173.1 bits, see alignment E=9.9e-55

Best Hits

Swiss-Prot: 45% identical to RIBD_ACTPL: Riboflavin biosynthesis protein RibD (ribD) from Actinobacillus pleuropneumoniae

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 72% identity to dar:Daro_0605)

MetaCyc: 64% identical to diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase (Burkholderia glumae)
Diaminohydroxyphosphoribosylaminopyrimidine deaminase. [EC: 3.5.4.26]; 5-amino-6-(5-phosphoribosylamino)uracil reductase. [EC: 3.5.4.26, 1.1.1.193]

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QLS7 at UniProt or InterPro

Protein Sequence (365 amino acids)

>Dsui_1267 riboflavin biosynthesis protein RibD (Dechlorosoma suillum PS)
MPAAPGTAADHAHMARALALAEQGLFSTSPNPRVGCVLVRDGVVVGEGWHVRAGEPHAEV
HALRAAGEAARGATAYVTLEPCSHHGRTPPCAEALVAAGVARVVAAMEDPNPLVAGRGLA
ILRQAGIEVCAGVLANEARELNIGFVSRMTRGRPWVRLKAASSLDGRTALANGQSQWITG
AEARQDGHRWRARACAILSGSGTVLADDPQLNVRGVDTERQPRPVVVDSRLQTPPTARLL
DGRPVLIATANPDLAKAAALAAQGAEVLLLPDAAGRVDLAALLLELGRRGINELHVEGGA
GLNGALLAAGLVDELLLYLAPTLLGNPALGLFGLPELTSLEQQQRLRWHDLRQVGGDLRI
LARLA