Protein Info for Dsui_1158 in Dechlorosoma suillum PS

Annotation: hydrogenase expression/formation protein HypE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 348 TIGR02124: hydrogenase expression/formation protein HypE" amino acids 15 to 348 (334 residues), 448.4 bits, see alignment E=7e-139 PF00586: AIRS" amino acids 48 to 161 (114 residues), 86.8 bits, see alignment E=1.4e-28 PF02769: AIRS_C" amino acids 175 to 325 (151 residues), 88.1 bits, see alignment E=7.1e-29

Best Hits

Swiss-Prot: 70% identical to HYPE_CUPNH: Carbamoyl dehydratase HypE (hypE) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: K04655, hydrogenase expression/formation protein HypE (inferred from 74% identity to app:CAP2UW1_0735)

Predicted SEED Role

"[NiFe] hydrogenase metallocenter assembly protein HypE" in subsystem NiFe hydrogenase maturation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QKV5 at UniProt or InterPro

Protein Sequence (348 amino acids)

>Dsui_1158 hydrogenase expression/formation protein HypE (Dechlorosoma suillum PS)
MKQNYIRPLDLKHGRVDMSHGSGGRAMAQLIDELFAPLLGNDYLAQGNDGSVMPLPDGPG
RLVMATDAHVVSPLFFPGGDIGCLSVHGTINDVAVMGAKPLYLSASFILEEGFALADLKR
IVESMAAAAREAGVPVVTGDTKVVEQGKGDGVFISTTGVGWLPAGIELSGNRAAAGDAIL
VSGPIGDHGMAIMSQRESLAFESPIVSDTAALHGLVADLLASGVQVKVLRDPTRGGLGTT
LNEIARQSGVGMMLQEARIPVQPAVAAACEFLGLDPLYCACEGRLIAIVAGEDKDKALAA
LQAHPQGTGAAIVGSVHEDPHHFVQMTTGFGGKRIVDWLTGEQLPRIC