Protein Info for Dsui_1108 in Dechlorosoma suillum PS

Annotation: AMP-forming long-chain acyl-CoA synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00501: AMP-binding
  • amino acids 25 to 442 (418 residues), 240 bits, E=4e-75
• PF23562: AMP-binding_C_3
  • amino acids 484 to 620 (137 residues), 33.7 bits, E=4.4e-12

Best Hits

KEGG orthology group: K01897, long-chain acyl-CoA synthetase [EC: 6.2.1.3] (inferred from 80% identity to dar:Daro_0249)

Predicted SEED Role

"Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1)" in subsystem ABC transporter branched-chain amino acid (TC 3.A.1.4.1) (TC 3.A.1.4.1)

MetaCyc Pathways

• superpathway of fatty acids biosynthesis (E. coli) (50/53 steps found)
• palmitate biosynthesis II (type II fatty acid synthase) (29/31 steps found)
• superpathway of fatty acid biosynthesis II (plant) (37/43 steps found)
• oleate β-oxidation (28/35 steps found)
• fatty acid salvage (5/6 steps found)
• long-chain fatty acid activation (1/1 steps found)
• palmitate biosynthesis III (21/29 steps found)
• phytol degradation (3/4 steps found)
• stearate biosynthesis II (bacteria and plants) (4/6 steps found)
• γ-linolenate biosynthesis II (animals) (1/2 steps found)
• linoleate biosynthesis II (animals) (1/2 steps found)
• octane oxidation (3/5 steps found)
• alkane biosynthesis II (1/3 steps found)
• oleate biosynthesis I (plants) (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• stearate biosynthesis IV (3/6 steps found)
• long chain fatty acid ester synthesis (engineered) (1/4 steps found)
• phosphatidylcholine acyl editing (1/4 steps found)
• wax esters biosynthesis II (1/4 steps found)
• 6-gingerol analog biosynthesis (engineered) (2/6 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• stearate biosynthesis I (animals) (1/6 steps found)
• arachidonate biosynthesis III (6-desaturase, mammals) (1/7 steps found)
• capsaicin biosynthesis (1/7 steps found)
• icosapentaenoate biosynthesis II (6-desaturase, mammals) (1/7 steps found)
• icosapentaenoate biosynthesis III (8-desaturase, mammals) (1/7 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)
• sporopollenin precursors biosynthesis (4/18 steps found)
• cutin biosynthesis (1/16 steps found)
• suberin monomers biosynthesis (2/20 steps found)

KEGG Metabolic Maps

• Fatty acid metabolism

Isozymes

Compare fitness of predicted isozymes for: 6.2.1.3

Use Curated BLAST to search for 6.2.1.3

Sequence Analysis Tools

See G8QK77 at UniProt or InterPro

Protein Sequence (659 amino acids)

>Dsui_1108 AMP-forming long-chain acyl-CoA synthetase (Dechlorosoma suillum PS)
MPEVASSQAAHTRNLTGETFPRLLFHHAQVRGQHPAMREKHLGIWQTWTWAEVAENVRAL
ACGLAELGFKRGDNLAIIGDNRPRLYMTMAAVQSLGGVPVPLYQDAVANEMLFVLQDAGI
RFAIVEDQEQVDKLLEVREQLPQLDHIIYDDPRGMRHYNQPFIHDIEAVMAMGRIHHQNH
PDFLEREIEQGVATDTGVMLYTSGTTGKPKGVCLAHQAFIAAAKGGCQFDQLTQDEDILS
YLPMAWVGDHLFSFAQALVAGFTINCPESGDTVMTDLREIGPTYYFAPPRVFENLLTQVM
IRMEDAGAIKHKLFAWAMDVAKRCGAEILDGKPVSGSDRLAYAVANLLVIGPLKNVLGMS
RIRVAYTAGAAIGPDLFRFYRSIGVNLKQLYGQTETCAYVCLQPDGQIKLDSVGKPAPGV
EVKIADNGEILVKGPMLLKEYYQRPDATAEAINGEGYFMTGDAGFFDEDGHLKIIDRAKD
VGKMANGAMFAPNYIENKLKFFQYVKEAVAFGNGREQVCAFINIDMGAVGNWAERRGISY
SGYTDLAAKPDVYNLIQECVEEVNAQLVHDGMLADSQIHRFLILHKELDPDDDELTRTRK
VRRNFVSEKYAVLIDAFYAGKTSQFIETQVKFEDGRVGKVAADLVIRDAKTFPVVRQAA