Protein Info for Dsui_1014 in Dechlorosoma suillum PS

Annotation: putative enzyme of thiazole biosynthesis

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 261 PF05690: ThiG" amino acids 5 to 253 (249 residues), 365 bits, see alignment E=8.6e-114

Best Hits

Swiss-Prot: 90% identical to THIG_DECAR: Thiazole synthase (thiG) from Dechloromonas aromatica (strain RCB)

KEGG orthology group: K03149, thiamine biosynthesis ThiG (inferred from 90% identity to dar:Daro_3861)

Predicted SEED Role

"Thiazole biosynthesis protein ThiG" in subsystem Thiamin biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QJJ3 at UniProt or InterPro

Protein Sequence (261 amino acids)

>Dsui_1014 putative enzyme of thiazole biosynthesis (Dechlorosoma suillum PS)
MEQLTIAGKTYRSRLIVGTGKYKDFAETRQAIDASGAEMVTVAIRRTNIGQDPNQPNLLD
ALPPSQFTILPNTAGCYTADEAVRTLRLARELLDGHALVKLEVLGDPTTLFPNMPETLKA
AEVLVKEGFQVMVYCADDPIQAKMLEEIGCAAVMPLASLIGSGMGILNPWNLRLIIDNAK
VPVIVDAGVGTASDAAIAMELGCDGVLMNTAIAHAGNPVLMASAMNKAVQAGREAFLAGR
MPRKLYSADPSSPTTGLIGKN