Protein Info for Dsui_0821 in Dechlorosoma suillum PS

Annotation: DNA topoisomerase III

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 861 TIGR01056: DNA topoisomerase III" amino acids 3 to 624 (622 residues), 547.2 bits, see alignment E=3.4e-168 PF01751: Toprim" amino acids 4 to 122 (119 residues), 34.8 bits, see alignment E=2.2e-12 PF01131: Topoisom_bac" amino acids 153 to 607 (455 residues), 386.9 bits, see alignment E=1.9e-119 PF13342: Toprim_Crpt" amino acids 657 to 715 (59 residues), 61.9 bits, see alignment 6.8e-21 amino acids 764 to 824 (61 residues), 62 bits, see alignment 6.3e-21

Best Hits

KEGG orthology group: K03169, DNA topoisomerase III [EC: 5.99.1.2] (inferred from 77% identity to app:CAP2UW1_0038)

Predicted SEED Role

"DNA topoisomerase III (EC 5.99.1.2)" in subsystem DNA topoisomerases, Type I, ATP-independent (EC 5.99.1.2)

Isozymes

Compare fitness of predicted isozymes for: 5.99.1.2

Use Curated BLAST to search for 5.99.1.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QHS7 at UniProt or InterPro

Protein Sequence (861 amino acids)

>Dsui_0821 DNA topoisomerase III (Dechlorosoma suillum PS)
MGKQLIIAEKPSVAADIAKALGGFTKHDDYFESDNFVLSSAIGHLLELVIPEEYEVKRGK
WSFAHLPVIPPHFELKPVEKTESRLKLLTKLIKRKDVDGLVNACDAGREGELIFNYIARH
AKSGKAVQRLWLQSMTPQAIRDGFARLRRGEEMQGLGDAAVCRSESDWLVGINGTRAMTA
FNSKTGGFHLTTVGRVQTPTLSLVVERERKIREFKARPYWEVEATFAAAAGEYKGKWFDE
AFKGKDEDEHARADRLWDEARAKALQAKCEGQPGEVSEEAKPSTQLSPLLFDLTSLQREA
NSRFGFSAKNTLGLAQALYEKHKVLTYPRTDSRALPEDYLGTVQATLQMFNGENLTKGSD
TSVVDRYGIFANKILKSKWVVPNKRIFNNAKISDHFAIIPTTQAPKNLSEPEQKLYDLVV
KRFLAVFFPAAEYLITTRITRVAGEPFKTEGKVLVNPGWLAIYGREGQEGDEGNLVAVSQ
GEKVQTEEVAVNQNETRPPARYSEATLLSAMEGAGKMVDDEELRAAMAGRGLGTPATRAQ
IIEGLITEQYLHREGRELIPTAKAFSLMTLLNGLGISELTSPELTGEWEWKLAQIERGDL
SRSAFMQEIEEMTRHIVDRAKSYDSDTVPGDFGLLKSPCPKCGGLMRETYKKFQCGDCDY
GLWKIVAGRQFEPEEIETLLTERQVGPLMGFRNKMGRPFNALIKLNDKNEPEFDFGQDRS
GEDGGEPVDFSGQESLGPCPKCGSPVYEHGLAYVCEKSVGPAKSCDFRSGKIILQQAVER
EQMQKLLSTGRTDLLKDFISARTRRKFSAFLVKGKDGKVSFEFEKREPKAPAAKKTAAKA
EPKAAVEKPTKAPAKRKAKEA