Protein Info for Dsui_0815 in Dechlorosoma suillum PS

Annotation: Zn-dependent protease with chaperone function

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 281 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details transmembrane" amino acids 33 to 49 (17 residues), see Phobius details amino acids 142 to 166 (25 residues), see Phobius details amino acids 178 to 198 (21 residues), see Phobius details PF01435: Peptidase_M48" amino acids 68 to 279 (212 residues), 125.8 bits, see alignment E=9.5e-41

Best Hits

Swiss-Prot: 80% identical to HTPX_RALPJ: Protease HtpX homolog (htpX) from Ralstonia pickettii (strain 12J)

KEGG orthology group: K03799, heat shock protein HtpX [EC: 3.4.24.-] (inferred from 83% identity to app:CAP2UW1_0044)

Predicted SEED Role

"Peptidase M48, Ste24p precursor"

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QHS1 at UniProt or InterPro

Protein Sequence (281 amino acids)

>Dsui_0815 Zn-dependent protease with chaperone function (Dechlorosoma suillum PS)
MSANWFKTTLLMAAIVALFGVIGGAVGGAQGMVIALLLGGAMNVFAYWNSDKMVLRMYNA
QQVDEASSPYLYNMVKELAGRAGLPMPRVYIIDEAQPNAFATGRNPENAAVAATTGILQM
LSQRELRGVMAHELAHVQHRDILISTISATMAGAISALANITMFFGGRDEEGRPANPLAS
ILVALLAPLAASLIQMAISRAREFEADRGGAQISGDPLALADALAKIDAYARGIPMPAAE
AHPETAQMMIMNPLSGGGLAGLFSTHPATEERIARLRQLAR