Protein Info for Dsui_0749 in Dechlorosoma suillum PS

Annotation: PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 953 transmembrane" amino acids 19 to 38 (20 residues), see Phobius details amino acids 194 to 213 (20 residues), see Phobius details PF00672: HAMP" amino acids 212 to 258 (47 residues), 40.8 bits, see alignment 9.2e-14 PF13188: PAS_8" amino acids 278 to 333 (56 residues), 21.3 bits, see alignment 8.1e-08 amino acids 403 to 447 (45 residues), 30.5 bits, see alignment 9.7e-11 PF00989: PAS" amino acids 278 to 388 (111 residues), 46 bits, see alignment E=1.9e-15 amino acids 404 to 510 (107 residues), 44.9 bits, see alignment E=4.4e-15 TIGR00229: PAS domain S-box protein" amino acids 279 to 398 (120 residues), 52.9 bits, see alignment E=4.1e-18 amino acids 404 to 520 (117 residues), 75.7 bits, see alignment E=3.4e-25 PF08448: PAS_4" amino acids 284 to 393 (110 residues), 62.9 bits, see alignment E=1.3e-20 amino acids 405 to 514 (110 residues), 37.5 bits, see alignment E=1e-12 PF13426: PAS_9" amino acids 290 to 390 (101 residues), 41.8 bits, see alignment E=4.5e-14 amino acids 410 to 512 (103 residues), 53.4 bits, see alignment E=1.1e-17 PF08447: PAS_3" amino acids 423 to 504 (82 residues), 37.7 bits, see alignment E=8e-13 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 520 to 687 (168 residues), 139 bits, see alignment E=1.2e-44 PF00990: GGDEF" amino acids 524 to 684 (161 residues), 164.1 bits, see alignment E=9.3e-52 PF00563: EAL" amino acids 705 to 939 (235 residues), 247 bits, see alignment E=6.9e-77

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QH66 at UniProt or InterPro

Protein Sequence (953 amino acids)

>Dsui_0749 PAS domain S-box/diguanylate cyclase (GGDEF) domain-containing protein (Dechlorosoma suillum PS)
MKSVPPIHQLPAPFRLKRLLPVVLLLSAILASLYVAQHWYQHASQRIEQESRETVGVLMR
QLQDILSERLVLDNLSQAKARLSATALHPRINTLILADEQHQVIFANRYLWQGQDAARVS
GYRPREADEAMGRDQHRIELNEAGTVLSGYFPLVLDLTHGSLRGLKRGTLYVEFDMTAPL
AAARSEAVEESLKTGALAVLGALLLSLLLDLWVTRRLQRISAAARRLGEGHLNERIGMAG
DDEIATLARQFDETAASLARKQDALQQADAQLQEHVQFMHTLIEAIPSPLFYKDAQGRYV
GCNEAFLTYLGKERHELLGKSVYDLAPKELADIYAAADRQLFDNPGKQVYESQACYADGS
KHDVIYNKATFMDAEGRVAGLVGVMVDITERKRQEEELRLAAKVFDTSNEAFLVTDADNN
IRSVNRAFCETTGYSAEEVLGRNPRLLSSGHHDKTFYRQMWEALNSQGYWQGEIYDRRKS
GEIYPKWTRINVVKDDQGRVVNHVAVFSDISDRKALEERLQFLAQHDHLTGLPNRNLLRL
RLEQAVESAMERGAGGINPVALLLLDLDHFKTINDSLGHHAGDQLLRTVVKRLKNILRES
STLCRQGGDEFLIVLPQAQDLARVSRAAETVLAALATPFEVDGHPLSITGSIGISLAPDD
GSDFDTLLKKADTALVHAKQSGRNAYRFFTEAMNVSTLERLTLQQRLHQALERQELVLYY
QPQLDLASGRVVGVEALLRWRTPEGLVPPGKFIPLAEETGLIVPMGAWVIQEACRQARTW
LDAGLPPMTMAVNLSALQFHRDNLLITVGDALSAASLPAASLELELTESILIQDAEATLA
TLKAMNAMGVLLSIDDFGTGYSSLAYLKRFTVDKLKIDQSFVRDITSDGDSAAIVRAVVQ
MASSLKLKTIAEGVETESQAAALRATGCDEVQGYLYARPMPAAECEAYLRGKA