Protein Info for Dsui_0417 in Dechlorosoma suillum PS

Annotation: gamma-glutamyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 54% identical to HPXW_KLEP7: Oxamate amidohydrolase proenzyme (hpxW) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K00681, gamma-glutamyltranspeptidase [EC: 2.3.2.2] (inferred from 57% identity to bgf:BC1003_5973)

Predicted SEED Role

"Gamma-glutamyltranspeptidase (EC 2.3.2.2)" in subsystem Glutathione: Biosynthesis and gamma-glutamyl cycle or Utilization of glutathione as a sulphur source (EC 2.3.2.2)

MetaCyc Pathways

glutathione degradation (DUG pathway) (1/2 steps found)
γ-glutamyl cycle (3/6 steps found)
leukotriene biosynthesis (1/6 steps found)
hypoglycin biosynthesis (4/14 steps found)
peptido-conjugates in tissue regeneration biosynthesis (3/17 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.2.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QPH5 at UniProt or InterPro

Protein Sequence (529 amino acids)

>Dsui_0417 gamma-glutamyltransferase (Dechlorosoma suillum PS)
MNPVLGTRGAVVASHSLAAQAGLDILREGGNAIEATIAVAATLAVVYPHMTGIGGDGFWL
LHAPGQPVRSIDACGAAGAQVTPELYGNLESIPWRGPLAANTVAGTVSGWAAAHAHSRAA
WGGRLPLSRLLESAIHYARHGFPVTRSQQDNTRAKLAELRQQPGFAAAFLNDGQLPVYGQ
QHRFPRLAETLEQLGRAGAEDFYRGDLAGVIARDLARVGSPVSGADLAAHRASLQDPLAV
KLSVGTVYNQAPPTQGVASLLILAIYDRIRREGWNPDNAEGIHALVEATKQAFLQRDRHV
GDPGSMQIDPRELLADGLVERLAAAIPLEQASPWPAPMSDGDTTWMGAIDSAGRAVSMIQ
SIYFEFGSGVVLPESGIWWQNRGCSFDLRPGWLRTLAPGRKPFHTLNPALARLDDGRLLV
YGTMGGEGQPQTQAAVFSRYVWGGHNVRSAVAAPRWLLGRTWAEQSTSLKLESRYDPALV
ERLRAMGHPVEMAGDFDERMGHAGALVLHPEGWIEGGEDPRSDGCVAAW