Protein Info for Dsui_0326 in Dechlorosoma suillum PS

Annotation: acyl-CoA dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 778 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 545 to 564 (20 residues), see Phobius details PF02771: Acyl-CoA_dh_N" amino acids 86 to 193 (108 residues), 73.1 bits, see alignment E=3.7e-24 PF00441: Acyl-CoA_dh_1" amino acids 321 to 468 (148 residues), 53 bits, see alignment E=6.6e-18 PF09317: ACDH_C" amino acids 475 to 759 (285 residues), 369.2 bits, see alignment E=2.8e-114

Best Hits

Swiss-Prot: 59% identical to FADE_YERPE: Acyl-coenzyme A dehydrogenase (fadE) from Yersinia pestis

KEGG orthology group: K06445, acyl-CoA dehydrogenase [EC: 1.3.99.-] (inferred from 78% identity to dar:Daro_1544)

Predicted SEED Role

"Butyryl-CoA dehydrogenase (EC 1.3.99.2)" in subsystem Acetyl-CoA fermentation to Butyrate or Anaerobic respiratory reductases or Butanol Biosynthesis or Isobutyryl-CoA to Propionyl-CoA Module or Isoleucine degradation or Valine degradation (EC 1.3.99.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.3.99.-, 1.3.99.2

Use Curated BLAST to search for 1.3.99.- or 1.3.99.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QNF1 at UniProt or InterPro

Protein Sequence (778 amino acids)

>Dsui_0326 acyl-CoA dehydrogenase (Dechlorosoma suillum PS)
MSIIPLLSVATLLTLAVLISVRPLRRALISRPLFSIYKRILPQMSDTEREALEAGSVWWE
GELFRGKPDWQKLMAYPQPKLTAEEQAFMDNEVDQACAMTDDWKVSHELYDLPPDVWQYI
KDKGFLGMIIPKKYGGLEFSAYAHSQVVTKLSTRSSALAVSVMVPNSLGPAELLLHYGTD
EQKNHYLPRLAKGIDVPAFALTSPWAGSDAASIPDYGVVCKGMWQGQEVLGMKVTWDKRY
ITLGPVCTVLGLAFRLYDPQGLLGDKKDIGITCALVPNDHPGVEIGTRHFPLNAAFHNGP
TRGKEVFMPLEFIIGGPKMAGQGWRMLMECLAAGRSISLPSSNTGMAKLTARAVGAYARV
RSQFKMAVGKFEGVEEALTRIGAYTYMMDAARVMTAGAVDLGEKPSVVSAIAKYHVTERA
RKVVNDGMDVIGGKGICLGPSNFLGRAYQQIPIGITVEGANILTRSLIIFGQGAIRCHPF
VLAEMQAAQKNDLVGFDKALFGHMGFSIGNGVRALLLGLTGARFAGVGADVAPETRRYYQ
QLTRFSSAFAFLSDVSMLVLGGGLKRKEKISARLGDILAQMYLISATLKRYEAEGRQQAD
AALMHWSVQDSLVQAQEAFDGVLANYPSPLVGWFLKKVIFPFGRPHVVPSDDIGHQVAKA
LISPSATRERLTAGCFVAKTEADAVGAIELALAATLEAEPIEAKIREAEKSGKFDGNPLA
NVRDVALAAYEAGVLSAAEYAVIKRRNELRDIVIRVDDFAPDFGVATALNKPEVRKAA