Protein Info for Dsui_0166 in Dechlorosoma suillum PS

Annotation: glutamate 5-kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01027: glutamate 5-kinase
  • amino acids 13 to 372 (360 residues), 443.4 bits, E=3.3e-137
• PF00696: AA_kinase
  • amino acids 13 to 241 (229 residues), 176.5 bits, E=7.7e-56
• PF01472: PUA
  • amino acids 284 to 357 (74 residues), 76.2 bits, E=1.6e-25

Best Hits

Swiss-Prot: 79% identical to PROB_DECAR: Glutamate 5-kinase (proB) from Dechloromonas aromatica (strain RCB)

KEGG orthology group: K00931, glutamate 5-kinase [EC: 2.7.2.11] (inferred from 81% identity to app:CAP2UW1_0761)

Predicted SEED Role

"Glutamate 5-kinase (EC 2.7.2.11) / RNA-binding C-terminal domain PUA" in subsystem Proline Synthesis (EC 2.7.2.11)

MetaCyc Pathways

• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• L-ornithine biosynthesis II (2/3 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• L-N^δ-acetylornithine biosynthesis (4/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.2.11

Sequence Analysis Tools

See G8QM70 at UniProt or InterPro

Protein Sequence (377 amino acids)

>Dsui_0166 glutamate 5-kinase (Dechlorosoma suillum PS)
MSPTTSRTANAGRLVVKVGSALVTNNGAGLDLAAIHEWARQIAELRHNGKQVVLVSSGAI
ACGMQRLGWQKRPKAVHELQAAAAVGQMGLAQVYESAFSAHGLHTAQILLTHDDLADRKR
YLNARATLTTLLELGVVPIINENDTVVTDEIKFGDNDTLGALVANLVEADCLIILTDQPG
LFTADPRKDPSATLITSARAGDPSLEAMAGGAGTQIGTGGMITKVLAAKRAARSGADTVI
ASGREKSPLTRLATGESVGTLLVADTLPMTARKQWLADHLQLAGKLTLDQGAIQALRQGK
SLLPVGVREVHGDFERGAAVACLDESGREIARGLCNYGSSEVRLIAKHSSSDIEDILGYM
EEPELIHRDNMVCLHEK