Protein Info for Dsui_0032 in Dechlorosoma suillum PS

Annotation: NAD-dependent protein deacetylase, SIR2 family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 276 PF02146: SIR2" amino acids 23 to 187 (165 residues), 71.7 bits, see alignment E=4e-24

Best Hits

KEGG orthology group: None (inferred from 67% identity to azo:azo0237)

Predicted SEED Role

"NAD-dependent protein deacetylase of SIR2 family" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Redox-dependent regulation of nucleus processes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See G8QKR9 at UniProt or InterPro

Protein Sequence (276 amino acids)

>Dsui_0032 NAD-dependent protein deacetylase, SIR2 family (Dechlorosoma suillum PS)
MQDPITTAAQYVLEADGLLITAGAGMGIDSGLPDFRGPEGFWRAYPALGLQRLMFEEIAC
PDAFVRDPEQAWGFYAHRLNLYRRTTPHAGFALLRAMAERLERGAFVFTSNVDGQFQKAG
FDELQVAECHGSLHHLQCFHDCRGHIWPAADFAPEVDEARCRLRSPLPRCPDCGALARPN
VLMFGDWNWQSGRTEVQRQRLENWLATVQRPVVIELGAGTAIPTVRWFGEMRGAPLIRIN
PGEAEVCTDRGVSLPLGAHVGLQAMARELRAAGFLD