Protein Info for CSW01_19425 in Vibrio cholerae E7946 ATCC 55056

Annotation: Lrp/AsnC family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 160 PF13412: HTH_24" amino acids 3 to 50 (48 residues), 61.6 bits, see alignment E=8.2e-21 PF13404: HTH_AsnC-type" amino acids 3 to 44 (42 residues), 51.9 bits, see alignment E=1e-17 PF01047: MarR" amino acids 10 to 50 (41 residues), 30.5 bits, see alignment E=5.4e-11 PF01037: AsnC_trans_reg" amino acids 69 to 143 (75 residues), 81.9 bits, see alignment E=5e-27

Best Hits

Swiss-Prot: 47% identical to LRP_KLEPN: Leucine-responsive regulatory protein (lrp) from Klebsiella pneumoniae

KEGG orthology group: K03719, Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein (inferred from 100% identity to vch:VCA1068)

Predicted SEED Role

"PutR, transcriptional activator of PutA and PutP" in subsystem Proline, 4-hydroxyproline uptake and utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (160 amino acids)

>CSW01_19425 Lrp/AsnC family transcriptional regulator (Vibrio cholerae E7946 ATCC 55056)
MSLDRVDRDILRILHAKGRLPVVELAKLVNLTTSPCSERVKRLEKEGYIRGYHADLDPGK
LGLDVQVFIHIRLDQSSFSIFERFAHAVADIPEIEACYSLSGDFDTMIKVRVKDMKAYQA
FMSGKLGSLPGVIQTRSEFVIEEHKTSFGINPELIYSLPS