Protein Info for CSW01_19315 in Vibrio cholerae E7946 ATCC 55056

Annotation: PTS mannitol transporter subunit IICBA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 649 transmembrane" amino acids 21 to 43 (23 residues), see Phobius details amino acids 49 to 68 (20 residues), see Phobius details amino acids 79 to 105 (27 residues), see Phobius details amino acids 132 to 153 (22 residues), see Phobius details amino acids 160 to 182 (23 residues), see Phobius details amino acids 214 to 235 (22 residues), see Phobius details amino acids 246 to 264 (19 residues), see Phobius details amino acids 270 to 293 (24 residues), see Phobius details amino acids 313 to 335 (23 residues), see Phobius details TIGR00851: PTS system, mannitol-specific IIC component" amino acids 9 to 344 (336 residues), 564.5 bits, see alignment E=3.6e-174 PF02378: PTS_EIIC" amino acids 18 to 278 (261 residues), 79.8 bits, see alignment E=3e-26 PF02302: PTS_IIB" amino acids 386 to 464 (79 residues), 43.1 bits, see alignment E=8.3e-15 PF00359: PTS_EIIA_2" amino acids 506 to 644 (139 residues), 121.9 bits, see alignment E=3.2e-39

Best Hits

Swiss-Prot: 100% identical to PTM3C_VIBCH: PTS system mannitol-specific EIICBA component (mtlA) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02798, PTS system, mannitol-specific IIA component [EC: 2.7.1.69] K02799, PTS system, mannitol-specific IIB component [EC: 2.7.1.69] K02800, PTS system, mannitol-specific IIC component (inferred from 100% identity to vch:VCA1045)

Predicted SEED Role

"PTS system, mannitol-specific IIC component (EC 2.7.1.69) / PTS system, mannitol-specific IIB component (EC 2.7.1.69) / PTS system, mannitol-specific IIA component (EC 2.7.1.69)" in subsystem Mannitol Utilization (EC 2.7.1.69)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (649 amino acids)

>CSW01_19315 PTS mannitol transporter subunit IICBA (Vibrio cholerae E7946 ATCC 55056)
MISSDAKVKIQNFGRFLSNMVMPNIGAFIAWGFITALFIPTGWVPNETLASLVGPMITYL
LPLLIGYTGGKLAGGERGAVVGAITTMGVIVGTDIPMFMGAMIVGPMGGWAIKAFDKKID
GKVRSGFEMLVNNFSAGIIGMLCAIIAFFLIGPFVKVLSGALAAGVNFLVTAHLLPLTSI
FVEPAKILFLNNAINHGIFSPLGIQQASETGQSIFFLIEANPGPGLGILLAYMVFGKGTA
RQTAGGATIIHFFGGIHEIYFPYILMNPRLILAAIAGGMTGVFTLTVFNAGLVSPASPGS
IFAVLLMTNKGSILGVVCSIFAAAAVSFTVAALLMKAQTSTEQDGDKDALVKATSIMQEM
KAGSKGQAAPTATQSKKIDMANVQSIIVACDAGMGSSAMGASMLRKKIQEVGLPVTVTNM
AINSLPAHVDMVITHQDLTDRARQHAPNAEHISLNNFLDSALYNQLVTQLLAAKRQAAND
SQLIKPSILAANDDRYEVQQPSVFQLQKENIHLGLNAKNKEEAIRFAGNKLVELGYVHPE
YVDAMFEREKLVSTYLGESIAVPHGTVDAKDRVIKTGIVICQYPQGVAFSEDSGDVAKLV
IGIAAKNDEHIQVITTITNALDDPNAIDKLTSTKDVSDVLSILATSQAA