Protein Info for CSW01_19170 in Vibrio cholerae E7946 ATCC 55056

Annotation: Na+/H+ antiporter NhaD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 477 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 29 to 51 (23 residues), see Phobius details amino acids 63 to 79 (17 residues), see Phobius details amino acids 97 to 114 (18 residues), see Phobius details amino acids 133 to 153 (21 residues), see Phobius details amino acids 155 to 167 (13 residues), see Phobius details amino acids 219 to 238 (20 residues), see Phobius details amino acids 259 to 277 (19 residues), see Phobius details amino acids 283 to 300 (18 residues), see Phobius details amino acids 346 to 367 (22 residues), see Phobius details amino acids 379 to 402 (24 residues), see Phobius details amino acids 413 to 440 (28 residues), see Phobius details amino acids 453 to 471 (19 residues), see Phobius details PF03600: CitMHS" amino acids 46 to 421 (376 residues), 122.5 bits, see alignment E=1.1e-39

Best Hits

Swiss-Prot: 100% identical to NHAD_VIBC3: Na(+)/H(+) antiporter NhaD (nhaD) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_0225)

Predicted SEED Role

"Na+/H+ antiporter NhaD type" in subsystem Na(+) H(+) antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (477 amino acids)

>CSW01_19170 Na+/H+ antiporter NhaD (Vibrio cholerae E7946 ATCC 55056)
MTGRIALLSLTLFSPLSLASTPDGQALDFTHSTIGYAALLIFAIAYTLVMLEEYLQLRKS
KPVLLAAGLIWAMIGYVYQQTGSTEVARQALEHNLLEYAELLLFLLVAMTYISAMEERRL
FDALKAWMINRGFNFHTLFWITGWLAFFISPIADNLTTALLMCAVVMKVGGENPKFVSLA
CINIVIAANAGGAFSPFGDITTLMVWQAGHVSFLEFMDLFLPSLANYLVPALVMSLFVPH
QTPSSIQEVVELKRGAKRIVVLFLFTILSAIGFHAFFHFPPVIGMMMGLAYLQFFGYFLR
KTLARSLAKKTAIAMAKNDEAALKRIGSVVPFDVFRSISHAEWDTLLFFYGVVMCVGGLS
LLGYLGLVSEILYTEWNPIWANVLVGLLSSVVDNIPVMFAVLSMQPEMSLGNWLLVTLTA
GVGGSLLSIGSAAGVALMGAAHGKYTFLSHLKWTPVILLGYVVSIVLHLLLNHQSFT