Protein Info for CSW01_18720 in Vibrio cholerae E7946 ATCC 55056
Annotation: hemin import ATP-binding protein HmuV
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to HMUV_VIBCH: Hemin import ATP-binding protein HmuV (hmuV) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
KEGG orthology group: K02013, iron complex transport system ATP-binding protein [EC: 3.6.3.34] (inferred from 100% identity to vco:VC0395_0322)Predicted SEED Role
"ABC-type hemin transport system, ATPase component" in subsystem Hemin transport system
Isozymes
Compare fitness of predicted isozymes for: 3.6.3.34
Use Curated BLAST to search for 3.6.3.34
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (259 amino acids)
>CSW01_18720 hemin import ATP-binding protein HmuV (Vibrio cholerae E7946 ATCC 55056) MQTIAIQGRDLCVTYGSRQVLDHVDITLRCGEVAALLGPNGAGKSTLLKLLCGEMSGAGK LDYFGVPASQWPAEKLANHLGILPQQSSLTFPFTAQEVVELGAIPLNLPRKEVERVARHY MLKTDVLHLAASLYPSLSGGEKQRLHLARVLTQLHQAGQQRILMLDEPTSALDLAHQHNT LQLARQLADEEQCAVVVVLHDLNLAAQYSDRLILLHQGKIVCDAAPWQALTAERIEQVYG YQALVAAHPTRDFPMVYPA