Protein Info for CSW01_18490 in Vibrio cholerae E7946 ATCC 55056
Annotation: cytochrome d ubiquinol oxidase subunit II
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 53% identical to CYDB_ECO57: Cytochrome bd-I ubiquinol oxidase subunit 2 (cydB) from Escherichia coli O157:H7
KEGG orthology group: K00426, cytochrome bd-I oxidase subunit II [EC: 1.10.3.-] (inferred from 100% identity to vcm:VCM66_A0832)MetaCyc: 53% identical to cytochrome bd-I subunit 2 (Escherichia coli K-12 substr. MG1655)
RXN0-5266 [EC: 7.1.1.7]; 1.11.1.- [EC: 7.1.1.7]; 1.11.1.- [EC: 7.1.1.7]
Predicted SEED Role
"Cytochrome d ubiquinol oxidase subunit II (EC 1.10.3.-)" in subsystem Bacterial RNA-metabolizing Zn-dependent hydrolases or Conserved gene cluster associated with Met-tRNA formyltransferase or Terminal cytochrome d ubiquinol oxidases or Terminal cytochrome oxidases (EC 1.10.3.-)
MetaCyc Pathways
- NADH to cytochrome bd oxidase electron transfer I (2/2 steps found)
- NADH to cytochrome bd oxidase electron transfer II (2/2 steps found)
- succinate to cytochrome bd oxidase electron transfer (2/2 steps found)
- pyruvate to cytochrome bd oxidase electron transfer (1/2 steps found)
Isozymes
Compare fitness of predicted isozymes for: 1.10.3.-
Use Curated BLAST to search for 1.10.3.- or 7.1.1.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (378 amino acids)
>CSW01_18490 cytochrome d ubiquinol oxidase subunit II (Vibrio cholerae E7946 ATCC 55056) MFEYDTLRLIWWGLIGALLIGFMITDGFDMGVGALLPILGQSESDKRVMINSIAPHWDGN QVWLITAGGALFAAWPLVYATSFSSLYIAMYLILLALWLRPLALEYRAKIDTPSWRKICD ISISLSGLIPPLLFGVAFGNLMQGLPFSLNALLMVDYHGSFIDLITPFSVLSGGIGVLMA LVQGSAWLTLKTSDILHKKARLTAQISVLCLFGLFIIGGFMVHGMNGYLIVSSLDYNAIS NPLNKVVFQQAGAWLTNFERYPWMWFAPMGGLMMAMGVFLSAKWKNDAITFVCASVTNAC IILTAGFAMFPFIMPSSFEPSHSLTLWDATSSERTLNIMTGVAFVMLPIILFYTAFSYRT MFGRLDKQYIERNHHSLY