Protein Info for CSW01_18485 in Vibrio cholerae E7946 ATCC 55056

Annotation: cytochrome d terminal oxidase subunit 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 530 transmembrane" amino acids 20 to 46 (27 residues), see Phobius details amino acids 58 to 77 (20 residues), see Phobius details amino acids 97 to 120 (24 residues), see Phobius details amino acids 132 to 152 (21 residues), see Phobius details amino acids 190 to 212 (23 residues), see Phobius details amino acids 224 to 242 (19 residues), see Phobius details amino acids 391 to 413 (23 residues), see Phobius details amino acids 425 to 447 (23 residues), see Phobius details amino acids 476 to 499 (24 residues), see Phobius details PF01654: Cyt_bd_oxida_I" amino acids 11 to 505 (495 residues), 575.3 bits, see alignment E=3.1e-177

Best Hits

Swiss-Prot: 70% identical to CYDA_ECOLI: Cytochrome bd-I ubiquinol oxidase subunit 1 (cydA) from Escherichia coli (strain K12)

KEGG orthology group: K00425, cytochrome bd-I oxidase subunit I [EC: 1.10.3.-] (inferred from 100% identity to vcj:VCD_000461)

MetaCyc: 70% identical to cytochrome bd-I subunit 1 (Escherichia coli K-12 substr. MG1655)
RXN0-5266 [EC: 7.1.1.7]; 1.11.1.- [EC: 7.1.1.7]; 1.11.1.- [EC: 7.1.1.7]

Predicted SEED Role

"Cytochrome d ubiquinol oxidase subunit I (EC 1.10.3.-)" in subsystem Terminal cytochrome d ubiquinol oxidases or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (530 amino acids)

>CSW01_18485 cytochrome d terminal oxidase subunit 1 (Vibrio cholerae E7946 ATCC 55056)
MGAFMIDVVELSRLQFALTAMFHFLFVPLTIGMSCLLAIMESIYVLTGKQIYQDMTRFWG
KLFGINFALGVTTGLTMEFQFGTNWSYYSHYVGDIFGAPLAIEALVAFFLESTFVGLFFF
GWSRLSKRQHLLITWLVALGSSFSALWILVANGWMQNPVGAEFNYQTMRMEMTSFAEVVL
NPVAQVKFLHTVASAYTCGAMFILGVSSYYLLQGRDIEFARRSFAIAATFGMAAIISVIV
LGDESGYKLGDVQKVKLAAIEAEWHTEPAPAAFTLFGLPNQKEGKTDYAIKIPYLMGLIA
TRSFDEQVTGLHDLRHEHLLRIRNGMVAYQLLERLQAGDASVETQRKFEQTKHDLGYGLL
LKRYTDTITDANEAQIQQAADDSMPTVWPLFWSFRIMVGCGFIMLFVFGAALLQTCRQRI
THKPWVLKAALWSIPLPWIAIEAGWFVAEYGRQPWAIGEVLPVTVAVSSQTFENLITSLA
IILSLYTVFIFVESYLIVTVARKGPSSLKTGRYQDEQSLYEHKLAQQVQY