Protein Info for CSW01_18455 in Vibrio cholerae E7946 ATCC 55056

Annotation: hemagglutinin/proteinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 609 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details PF07504: FTP" amino acids 53 to 97 (45 residues), 42.4 bits, see alignment 1.2e-14 PF03413: PepSY" amino acids 119 to 190 (72 residues), 26.4 bits, see alignment E=1.8e-09 PF01447: Peptidase_M4" amino acids 208 to 351 (144 residues), 115.8 bits, see alignment E=5.7e-37 PF02868: Peptidase_M4_C" amino acids 354 to 498 (145 residues), 117.9 bits, see alignment E=1.1e-37 PF04151: PPC" amino acids 529 to 597 (69 residues), 70.7 bits, see alignment E=4e-23

Best Hits

Swiss-Prot: 100% identical to HAPT_VIBCH: Hemagglutinin/proteinase (hap) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K08604, vibriolysin [EC: 3.4.24.25] (inferred from 100% identity to vcj:VCD_000466)

Predicted SEED Role

"Vibriolysin, extracellular zinc protease (EC 3.4.24.25) @ Pseudolysin, extracellular zinc protease (EC 3.4.24.26)" (EC 3.4.24.25, EC 3.4.24.26)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.24.25 or 3.4.24.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (609 amino acids)

>CSW01_18455 hemagglutinin/proteinase (Vibrio cholerae E7946 ATCC 55056)
MKMIQRPLNWLVLAGAATGFPLYAAQMVTIDDASMVEQALAQQQYSMMPAASGFKAVNTV
QLPNGKVKVRYQQMYNGVPVYGTVVVATESSKGISQVYGQMAQQLEADLPTVTPDIESQQ
AIALAVSHFGEQHAGESLPVENESVQLMVRLDDNQQAQLVYLVDFFVASETPSRPFYFIS
AETGEVLDQWDGINHAQATGTGPGGNQKTGRYEYGSNGLPGFTIDKTGTTCTMNNSAVKT
VNLNGGTSGSTAFSYACNNSTNYNSVKTVNGAYSPLNDAHFFGKVVFDMYQQWLNTSPLT
FQLTMRVHYGNNYENAFWDGRAMTFGDGYTRFYPLVDINVSAHEVSHGFTEQNSGLVYRD
MSGGINEAFSDIAGEAAEYFMRGNVDWIVGADIFKSSGGLRYFDQPSRDGRSIDHASQYY
SGIDVHHSSGVFNRAFYLLANKSGWNVRKGFEVFAVANQLYWTPNSTFDQGGCGVVKAAQ
DLNYNTADVVAAFNTVGVNASCGTTPPPVGKVLEKGKPITGLSGSRGGEDFYTFTVTNSG
SVVVSISGGTGDADLYVKAGSKPTTSSWDCRPYRSGNAEQCSISAVVGTTYHVMLRGYSN
YSGVTLRLD