Protein Info for CSW01_18390 in Vibrio cholerae E7946 ATCC 55056

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 359 transmembrane" amino acids 12 to 34 (23 residues), see Phobius details amino acids 40 to 59 (20 residues), see Phobius details amino acids 70 to 90 (21 residues), see Phobius details amino acids 102 to 121 (20 residues), see Phobius details PF06580: His_kinase" amino acids 151 to 229 (79 residues), 82.1 bits, see alignment E=2.7e-27 PF02518: HATPase_c" amino acids 249 to 338 (90 residues), 33.7 bits, see alignment E=4.3e-12

Best Hits

KEGG orthology group: None (inferred from 99% identity to vco:VC0395_0386)

Predicted SEED Role

"Autolysin sensor kinase (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (359 amino acids)

>CSW01_18390 sensor histidine kinase (Vibrio cholerae E7946 ATCC 55056)
MMERFDISAQDLKSFGFTTLFCIVIALATMSIWGGLFGEHLAISFSYGYSAFFSAQWIAR
RWPELSKRLVNILSLSCAVVLGTSSAYLWLRHYPGFDEFSAYKPIIFLGFIFSAVCFLYF
YSHEQKILAQGALEAARRRQSEQEKALLLSQLKQLQSQMEPHFLFNTLANINALIAVEPY
KAQLMLEKLTELLRGTMRLRRTNTGDLREEMQLIDAYLGIQKIRLGERLEYTLPELSELG
TLGMPPMLIQPLVENAVSHGIEPKAEGGTIRVRIEVADDWFELSVEDNGMGLSDTPKGNG
IALQNVRDRLSGLFGHEGLLTVAQNCSGGVTATLRIRLHHLQGLQRSFYDYSQARSPQS