Protein Info for CSW01_18190 in Vibrio cholerae E7946 ATCC 55056

Annotation: exoribonuclease 2

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 678 TIGR02062: exoribonuclease II" amino acids 1 to 649 (649 residues), 1160.1 bits, see alignment E=0 TIGR00358: VacB and RNase II family 3'-5' exoribonucleases" amino acids 6 to 648 (643 residues), 617.1 bits, see alignment E=3.6e-189 PF08206: OB_RNB" amino acids 24 to 80 (57 residues), 56.5 bits, see alignment 3.5e-19 PF00773: RNB" amino acids 193 to 521 (329 residues), 291.3 bits, see alignment E=2.1e-90 PF00575: S1" amino acids 564 to 645 (82 residues), 31.9 bits, see alignment E=2.8e-11

Best Hits

Swiss-Prot: 100% identical to RNB_VIBCM: Exoribonuclease 2 (rnb) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K01147, exoribonuclease II [EC: 3.1.13.1] (inferred from 100% identity to vch:VCA0805)

Predicted SEED Role

"Exoribonuclease II (EC 3.1.13.1)" in subsystem RNA processing and degradation, bacterial (EC 3.1.13.1)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.1.13.1

Use Curated BLAST to search for 3.1.13.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (678 amino acids)

>CSW01_18190 exoribonuclease 2 (Vibrio cholerae E7946 ATCC 55056)
MFQDNPLLAQLKQKIQETLPKKEGTIKASDKGFGFLEVDSKTSYFVPPPYMKKCMHGDKV
VAFIRTENEREVAEPSELIEQSLTRFIGRVKLFKGKLNVAPDHPQLKKLSLKAKTKKGLN
EADFQEGDWVVAHLVRHPLKGDDGFFVQISHKITDANDKIAPWWVTLAENDLPNSEPAGI
DDWQLKDDADLVREDLTALPFVTIDGESTKDMDDALYAQQLPNGDFALTIAIADPTAYIT
PEDEMDKVARERGFTIYLPGRNIPMLPRDLADELCSLMENQVRPALCCSVTIRKDGVIGD
DIRFFAANIKSHARLVYDHVSDWLETGSSEQWQPSEEIAQVVRDLYAFSQARANWRETHA
VVFPDRPDYRFELSADNDVVAIHADMRRTANRLVEESMITANICAGKTLQTTFGFGVFNT
HAGFKAEKMADVVELMAVNGAPNADAETLATVEGFAALRRWLATQETSYLDNRIRKYQSY
SEIGNQPLPHFAMGLDVYATWTSPIRKYGDMINHRLLKAHILGKAPVQTPDETVGEELAL
HRKHHKIAERNVADWLYARTLADEPAKETRFQAEIFDINRPGMRVRLLENGAMAFIPGAL
ILDNKERIECNGEDGTVLIDKEVVYKLGDVLEIVLTEVNQENRSLVGKPTQVFADLVSET
QTSAEQPAEGAENNEPQV