Protein Info for CSW01_17675 in Vibrio cholerae E7946 ATCC 55056

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 642 transmembrane" amino acids 23 to 43 (21 residues), see Phobius details amino acids 320 to 345 (26 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 358 to 475 (118 residues), 65.9 bits, see alignment E=3.9e-22 PF08448: PAS_4" amino acids 366 to 469 (104 residues), 29.9 bits, see alignment E=1.4e-10 PF00989: PAS" amino acids 366 to 459 (94 residues), 38.4 bits, see alignment E=2.8e-13 PF13426: PAS_9" amino acids 366 to 466 (101 residues), 59.7 bits, see alignment E=7.5e-20 PF08447: PAS_3" amino acids 376 to 459 (84 residues), 28.5 bits, see alignment E=3.7e-10 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 477 to 632 (156 residues), 133.2 bits, see alignment E=7.7e-43 PF00990: GGDEF" amino acids 481 to 629 (149 residues), 126.7 bits, see alignment E=1.8e-40

Best Hits

KEGG orthology group: None (inferred from 100% identity to vcj:VCD_000620)

Predicted SEED Role

"Sensory box/GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (642 amino acids)

>CSW01_17675 GGDEF domain-containing protein (Vibrio cholerae E7946 ATCC 55056)
MIRSIVCTQRLIHRIMYTSARKYFIQFAIVAFVLGFIPTLYFIHAASQLETQAVSSVEKQ
TRLQLEFSQHDLLRMLESTHQATQLLAKNDLLFTAVTTPSKEALSQLKTLWDVTLRSQAI
FSSFRLLDRQGKEQLKAIYDGHQVTFVESAQTTDPFSQQIVAQYAQLTTPQVWATQVAMS
ADTPSGMLPTFRFVTGIEHQGQRQGFLVVTVKLQSLYQRLSFIYDQFDSPDILNSAGELL
LSEHKPSGTRSTSSLHFSAQHPELWQKIQLNQQGFALSNQTWFSYIKVDLSSVLPDFKPL
VLVLRINKAEIDKTYANARWALMSQAVTVLSLLSIIAAGFAAWNINHLKNSLDSKLARAA
MDGMSAVVITDRQNRIIKVNNEFTRLSGYTFEDVKGKQPSIFASGLHKVEFYMQMWKALQ
DNGVWEGEVINKRKDGESITEILRIQSIRDEDNVIQFYVASFVDISHRKALENRLRELSE
KDALTDLWNRRKFDQTISLECAKRRRYPDQAQSCLAIIDIDHFKRINDKFGHNEGDLVLR
TVAKGIQDQLRESDFIARIGGEEFAIIFPYTSIEEAEQVLNRVRLHIASLHHQQVTLSGG
VTDVCTSPDQSYKRADLALYESKTSGRNQISVLTAMEMHHFA