Protein Info for CSW01_17295 in Vibrio cholerae E7946 ATCC 55056

Annotation: molybdopterin molybdotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 411 PF03453: MoeA_N" amino acids 10 to 171 (162 residues), 155.7 bits, see alignment E=1.3e-49 TIGR00177: molybdenum cofactor synthesis domain" amino acids 180 to 317 (138 residues), 109.3 bits, see alignment E=8.2e-36 PF00994: MoCF_biosynth" amino acids 185 to 320 (136 residues), 104.9 bits, see alignment E=4.7e-34 PF03454: MoeA_C" amino acids 336 to 406 (71 residues), 76.8 bits, see alignment E=1.8e-25

Best Hits

Swiss-Prot: 61% identical to MOEA_SALTY: Molybdopterin molybdenumtransferase (moeA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03750, molybdopterin biosynthesis protein MoeA (inferred from 100% identity to vcm:VCM66_A0575)

MetaCyc: 58% identical to molybdopterin molybdotransferase (Escherichia coli K-12 substr. MG1655)
RXN-8348 [EC: 2.10.1.1]

Predicted SEED Role

"Molybdopterin biosynthesis protein MoeA" in subsystem Molybdenum cofactor biosynthesis

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.10.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (411 amino acids)

>CSW01_17295 molybdopterin molybdotransferase (Vibrio cholerae E7946 ATCC 55056)
MGCCDAPGLMPIEDALKKMLSRIQPVQTTLRLPLPEALGYVLAEAILSPIHVPPFDNSAM
DGYAVRRAELAQQKPLPVAGKSFAGQPFTADWPPMTCVRIMTGAQIPAGCDAVIMQEQAT
ITEEGVVFCQHEVKLNDNIRPTGDDIRQNDVVLERGARLTARDIPMIATLGISHVTVYRK
PKVAFFSTGDELKPLGEPLQAGQIYDSNRYGIKPLIENFGCEAIDLGIVPDCPATLKATF
EQAQSLADVVVTSGGVSVGEADYTKDILEELGEIGFWKLAIKPGKPFAFGALQDAWFCGL
PGNPVSAVLTMYVLVQPMLAKLAGHSAWQAPESIPAITRSPFKKAPGRTDFQRGIYRIEN
GQFVVESTGNQSSGAFRSMSLANCFVVLERERGRVEVGETVQIQLFNPTLY