Protein Info for CSW01_17240 in Vibrio cholerae E7946 ATCC 55056

Annotation: 2-aminoethylphosphonate--pyruvate aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 367 signal peptide" amino acids 1 to 16 (16 residues), see Phobius details TIGR02326: 2-aminoethylphosphonate--pyruvate transaminase" amino acids 2 to 365 (364 residues), 631.2 bits, see alignment E=5.1e-194 TIGR03301: 2-aminoethylphosphonate aminotransferase" amino acids 6 to 361 (356 residues), 539.5 bits, see alignment E=4.5e-166 PF00266: Aminotran_5" amino acids 37 to 313 (277 residues), 90.3 bits, see alignment E=1.3e-29 PF00155: Aminotran_1_2" amino acids 61 to 356 (296 residues), 27.1 bits, see alignment E=2.5e-10

Best Hits

Swiss-Prot: 100% identical to PHNW_VIBCM: 2-aminoethylphosphonate--pyruvate transaminase (phnW) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K03430, 2-aminoethylphosphonate-pyruvate transaminase [EC: 2.6.1.37] (inferred from 100% identity to vcj:VCD_000715)

Predicted SEED Role

"2-aminoethylphosphonate:pyruvate aminotransferase (EC 2.6.1.37)" in subsystem Phosphonate metabolism (EC 2.6.1.37)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.37

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (367 amino acids)

>CSW01_17240 2-aminoethylphosphonate--pyruvate aminotransferase (Vibrio cholerae E7946 ATCC 55056)
MKNAYLLLTPGPLSTSESVREAMLKDWCTWDDDYNLEIVEVIRRKLVTLATTQSGYTSVL
MQGSGTASVEATIGSVMLPTDKLLVIDNGAYGARIAQIAQYLNIACRVIAPGETAQPNLD
EIADVLTHDPAITHVAIVHCETTTGMLNPIAEVAKIAKQHGKRVILDAMSSFGGIPMDIG
ALGIDFMISSANKCIQGVPGFGFVIAKRSELEQCQGRARSLTLDLFDQWQCMEKNHGKWR
FTSPTHTVRAFYQALLELESEGGIAARYQRYQTNQTQLVKGMRELGFAPLLPEKLHSPII
TSFYSPEHSDYQFAEFYQRLKQQGFVIYPGKVSHADCFRIGNIGEVYPQDIERLLSAMQH
AIYWQQA