Protein Info for CSW01_17105 in Vibrio cholerae E7946 ATCC 55056

Annotation: TonB-dependent hemoglobin/transferrin/lactoferrin family receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 698 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details TIGR01785: TonB-dependent heme/hemoglobin receptor family protein" amino acids 32 to 698 (667 residues), 445.4 bits, see alignment E=3.8e-137 TIGR01786: TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein" amino acids 33 to 698 (666 residues), 501.8 bits, see alignment E=3.5e-154 PF07715: Plug" amino acids 47 to 156 (110 residues), 86.1 bits, see alignment E=2.2e-28 PF00593: TonB_dep_Rec_b-barrel" amino acids 222 to 662 (441 residues), 222.4 bits, see alignment E=2.2e-69

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 100% identity to vcm:VCM66_A0535)

Predicted SEED Role

"TonB-dependent heme and hemoglobin receptor HutA; TonB-dependent hemin , ferrichrome receptor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (698 amino acids)

>CSW01_17105 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor (Vibrio cholerae E7946 ATCC 55056)
MQVVQMYKKSLLSSAIMLALVPSAYADDYASFDEVVVSTTRLNTQITDTAASVAVINASD
IEQQMAEDIEGLFKYTPGVTLTTNSRQGVQGINIRGIEGNRIKVIVDGVAQPNQFDSGNS
FLNSSRVDIDTDMVKSVEIVKGAASSLQGSDAIGGIVAFETKDPADILKGRNMGGYAKLN
YSSSDKTFSESIALANKSGDLESLVAYTRRDGQEIQNFGSPDQQDNNANNLLVKLQYQLN
PKHRLEFSGNYIRNKNDLENLEFSGYKNASGTDETTQYQLGIKHIWDAEFSLADRITWQF
DVVGKEETGITDRTSKSNGNIQKKDYLYSDKGFSFDSQLDKSFMVSNTEHYIVYGFSLSD
KDIENTNQEFNSIGKNNVIFYIPNASEKRYGFFIQDEIAFDNLIVTPGIRFDSFETKPGD
TSANPSLNDASEYKKYSDSALTARLGTVYKLNQENRLFAQISQGFRAPDFQELYYSFGNP
AHGYVFKPNPNLEAEDSVSYELGWRYNADSVSNELSIFYSDYDNFIDSQIVSGSFKTRDA
VHQSINIDKATIKGIELSNQFFWDRFMPIVGFSSRIAAAYTEGKDGNGKPLNSVSPWNAV
TGINYDSENNWGTAVNLTYTAKKKASEINGDYQPISSATVIDVTAYYKPIKDLTLRAGVF
NLTDEEYYNWNDVRGLPSEDKDKTQAKRNFGITAKYEF