Protein Info for CSW01_16890 in Vibrio cholerae E7946 ATCC 55056

Annotation: sensor histidine kinase KdpD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 497 transmembrane" amino acids 12 to 28 (17 residues), see Phobius details amino acids 35 to 52 (18 residues), see Phobius details amino acids 57 to 72 (16 residues), see Phobius details amino acids 85 to 105 (21 residues), see Phobius details PF13493: DUF4118" amino acids 12 to 116 (105 residues), 57 bits, see alignment E=2.2e-19 PF00512: HisKA" amino acids 270 to 334 (65 residues), 51.8 bits, see alignment E=1e-17 PF02518: HATPase_c" amino acids 380 to 487 (108 residues), 97.6 bits, see alignment E=9e-32

Best Hits

KEGG orthology group: K07646, two-component system, OmpR family, sensor histidine kinase KdpD [EC: 2.7.13.3] (inferred from 100% identity to vcm:VCM66_A0490)

Predicted SEED Role

"Osmosensitive K+ channel histidine kinase KdpD (EC 2.7.3.-)" in subsystem Potassium homeostasis (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (497 amino acids)

>CSW01_16890 sensor histidine kinase KdpD (Vibrio cholerae E7946 ATCC 55056)
MVTRLNEAHKALILVALYAMVTVVGVMYRKDMIETDVAMLFLLLNILSASVLKPRNAYVM
MGLSIIDYHYFLLPDYQSFRFENAQYVITYAVLAFSGIFAVNITQAQRKQIEKNKRLQQQ
HKKYYELACHLSALSTSEDIAQATVKFLSKEKGIVSAIALYQPQWQWVAQHADFPVAAIE
LPQPPLTDNTSTLVQDEQINAFTLVDRGTILGVIYFLRYPHERFASPEALRRESKIAPWV
RSLLTLSLARAHAHRTLAHVEAEKQLESTRTTLLASVSHDLKTPLGAIIGSATTLTDPSL
HLSTETQQELLTSIAEQGERLNRSLTKLLDITRYTASALVPKLDWVEPEELIGTVLSRLA
PRLTHHKVQIESQPMLVELDSLLIEQVLINLVENAAKYTPRGSEIEIACAYQEQQFTLAV
MDNGAGIPDEALPRIFDRFYRVEGNHADGTGLGLAICQVIVAAHQGSIRVHNRESGGACF
TVTIPCRQYNLKELYEQ